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Pregnenolone is a steroid hormone manufactured primarily in the adrenal glands, similar to testosterone, DHEA, and other sex hormones. Smaller amounts of pregnenolone are also produced in other organs such as the brain, skin, gonads, liver, and eyes. Among women, adequate pregnenolone is essential in treating overall hormone imbalance, symptoms related to menopause, and maintaining a positive mood.
In the body, all hormones work in harmony to create a healthy balance. If you picture steroid hormones as a cascade, where one hormone has an impact on one another, pregnenolone would be at the top of the cascade. Because of this, some researchers have nicknamed pregnenolone the “master hormone” or “mother hormone.”
Pregnenolone is manufactured directly from cholesterol. Some experts believe that low cholesterol can lead to hormone imbalance because your body doesn’t have sufficient raw material to produce enough pregnenolone. This in turn would affect levels of estrogen, DHEA, testosterone, and other hormones synthesized from pregnenolone.
Pregnenolone is also used to create neurohormones in the brain. These neurohormones are used to regulate mood, meaning it’s essential to maintain adequate pregnenolone to avoid mood-related disorders.
Unfortunately, there is still much we don’t know about pregnenolone, mostly because the research community has focused on steroid hormones like estrogen and progesterone. In the 1940s, when the focus of research is on how adrenal hormones worked, pregnenolone was extensively studied together with cortisol as an anti-inflammatory. In the 1950s, researchers discovered how to make synthetic cortisol, so the study of pregnenolone declined. Because pregnenolone, unlike cortisone, couldn’t be patented, there was no financial incentive to pursue the research.
Today, pregnenolone is used to improve energy, vision, memory, cognition, well-being, and sexual enjoyment or libido. It is considered a brain enhancer, and studies have shown that it is one of the most effective and powerful memory boosters. Women use pregnenolone for treatment of lumpy breasts (fibrocystic breast disease), endometriosis (disorder in the lining of the uterus), hot flashes, and other premenstrual symptoms.
As women age, levels of pregnenolone can fall as much as 60 percent. Researchers have linked this decline to depression, anxiety, cognitive impairment, and other mental illness. In women, low levels of pregnenolone are associated with low energy and mood and increased symptoms of menstruation. Other symptoms related to low pregnenolone include:
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Women are at higher risk for hormone imbalance, thanks to their more complicated hormonal picture. Because of its role as the mother hormone, pregnenolone is frequently included in bioidentical hormone programs so there is plenty of material to make other sex hormones. Pregnenolone is also used to help relieve various symptoms of menopause. Other benefits of pregnenolone include:
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With pregnenolone supplementation, the goal is to support overall healthy levels of pregnenolone in order to stimulate the body to produce internal pregnenolone in areas that need a boost of another steroid hormone. Pregnenolone is available in the form of injections, tablets, and topical creams.
Pregnenolone is a steroid hormone similar to testosterone, DHEA and other sex hormones. It is manufactured primarily in the adrenal glands, but smaller amounts are also produced in other organs including the skin, brain, gonads, liver and even the eyes.
In the body, all hormones work together to create a healthy balance. If you picture steroid hormones as a cascade, where one hormone affects another, and hormones can be synthesized from each other, pregnenolone would be at the top of the cascade. It’s manufactured directly from cholesterol (which is one reason that some experts believe excessively low cholesterol can actually contribute to a hormone imbalance). In turn, other hormones such as testosterone, DHEA, estrogen, and cortisol are synthesized from pregnenolone. Low pregnenolone levels are directly related to an overall deficiency in other, more biologically active hormones.
Pregnenolone is also highly concentrated in the brain, where it helps maintain cognitive health and healthy brain function. Just as it’s used to synthesize other steroid hormones, pregnenolone is used to create neurohormones in the brain, which act to support healthy nerve cell function and regulate mood. Because pregnenolone levels fall dramatically with age, as much as 60 percent, some researchers have linked pregnenolone deficiency in older adults to depression, anxiety, cognitive deficits and mental illness.
Besides acting as the main precursor for most steroid hormones, pregnenolone has a number of important functions in the body. Low levels of pregnenolone have been linked to memory problems and cognitive deficits, fatigue and low energy, low mood, and even increased symptoms of menstruation.
Unfortunately, researchers haven’t focused on the specific effects of pregnenolone in the body. This has more to do with how drugs are researched than it has to do with pregnenolone. In the 1940s, when researchers were just beginning to unravel how adrenal hormones worked, pregnenolone was extensively studied alongside cortisol for the relief of inflammatory conditions such as arthritis. In the 1950s, however, researchers figured out how to make synthetic cortisol, so the research focused on the more profitable hormone and the study of pregnenolone by itself declined.
Because of its role as the body’s main steroid hormone precursor, pregnenolone is typically included in a comprehensive hormone panel. Low levels are often indicative of an overall hormone imbalance and deficiency. However, it’s hard to isolate specific symptoms caused by low pregnenolone because these symptoms likely overlap with more powerful downstream hormones such as testosterone.
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Bioidentical hormone replacement programs tend to use pregnenolone as a general balancing hormone. There is some evidence that healthy pregnenolone levels support overall healthy hormone levels, as well as boost the immune system, reduce stress and prolong life. Pregnenolone is effectively used alongside testosterone and estrogen to help relieve symptoms of estrogen imbalance, andropause and testosterone deficiency in men.
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In the body, which hormone created from pregnenolone depends on where the pregnenolone is synthesized. For example, pregnenolone which is synthesized in the adrenal glands (the majority of it) is likely to be used to create cortisone or the body’s main stress hormone. Pregnenolone synthesized in the ovaries, by contrast, is likely to be used to synthesize estrogen. With pregnenolone supplementation, the goal is to support overall healthy levels of pregnenolone, which encourages the body to make internal pregnenolone in areas that need a boost of another steroid hormone. Pregnenolone can also be applied topically, and there is some evidence it can reduce wrinkles and improve skin elasticity.
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