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Cialis

Cialis

Cialis is the brand name of the generic drug known as tadalafil. It is mainly used for treatment of erectile dysfunction. Its mechanism of action works by relaxing the blood vessels in the penis. This in turn increases blood flow going to the penis, resulting in an erection. Studies show that Cialis is not just a medication for ED but also for different medical conditions.

Overall Health Benefits

  • Improves erection [1-27]
  • Lowers risk of heart disease [28-33]
  • Treats complex regional pain syndrome (CRPS) [34]
  • Fights depression [35]
  • Treats pulmonary arterial hypertension (PAH) [36]

Proven Health Benefits

Improves Erection

An overwhelming body of clinical evidence supports the safety and efficacy of Cialis in the treatment of erectile dysfunction:

  1. Several studies suggest that Cialis administration can help improve and maintain erections in men with erectile dysfunction without any adverse side effects. [1-19]
  2. In diabetic patients, Cialis treatment resulted in improved erections. [20]
  3. In men with mild to moderate impairments in erectile function, Cialis treatment once daily significantly improved erectile function. [21]
  4. In men with erectile dysfunction, Cialis treatment once daily improved satisfaction, psychosocial outcomes, and spontaneous erections. [22]
  5. In patients taking antidepressant medications, Cialis treatment was well tolerated and improved erectile function. [23]
  6. In patients who had surgical removal of the prostate, Cialis improved morning erections. [24]
  7. In men with erectile dysfunction following spinal cord injury, Cialis treatment for 4 weeks improved erections. [25]
  8. In men with erection problems, sustained improvement in sexual function after 12 months of Cialis administration was caused by an increase in testosterone. [26]
  9. In rats with erectile dysfunction due to spinal cord injury, Cialis administration improved erectile function. [27]

Lowers Risk of Heart Disease

A number of convincing studies support the cardioprotective effects of Cialis:

  1. A study has shown that Cialis administration protected against cardiovascular disease. [28]
  2. A clinical trial showed that Cialis administration can help improve cardiovascular health in patients with or without heart disease. [29]
  3. In adult male mice, Cialis administration produced cardioprotective effects. [30]
  4. In mouse models, Cialis treatment reduced the narrowing of arteries, thus preventing heart failure. [31]
  5. In rats, Cialis supplementation prevented future complications through its protective effects against heart disease. [32]
  6. In a mouse model, Cialis treatment demonstrated protective effects against heart dysfunction. [33]

Treats Complex Regional Pain Syndrome (CRPS)

Evidence suggests that Cialis has potent pain-relieving properties.

In one study, a daily dose of Cialis relieved pain in patients with CRPS, a condition characterized by excess and prolonged pain and inflammation resulting from an injury or trauma. [34]

Fights Depression

A study also reported that Cialis has antidepressant effects.

In a study of men experiencing depression due to erectile dysfunction, a daily dose of Cialis eliminated depressive symptoms and improved their mood. [35] Researchers believed that this was associated with improvement in sexual function following the treatment.

Treats Pulmonary Arterial Hypertension (PAH)

PAH, also known as pulmonary hypertension, is characterized by high blood pressure in the lungs. This increased pressure in the blood vessels results from obstruction in the small arteries. Evidence shows that Cialis can help treat this lung condition.

In one clinical trial, patients with PAH were given Cialis to assess the effects of the medication. [36] Results showed that the patients demonstrated significantly improved exercise capacity, decreased clinical complications, improved cardiopulmonary hemodynamics, and increased quality of life.

References:

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  2. Frajese GV, Pozzi F, Frajese G. Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence. Clin Interv Aging. 2006;1(4):439-449. doi:10.2147/ciia.2006.1.4.439.
  3. Guo YL, Viswanathan VP, Chiang HS, et al. Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis. Asian J Androl. 2009;11(4):423-433. doi:10.1038/aja.2009.11.
  4. Young JM, Feldman RA, Auerbach SM, Kaufman JM, Garcia CS, Shen W, Murphy AM, Beasley CM Jr, Hague JA, Ahuja S. Tadalafil improved erectile function at twenty-four and thirty-six hours after dosing in men with erectile dysfunction: US trial. J Androl. 2005 May-Jun;26(3):310-8. doi: 10.2164/jandrol.04126. PMID: 15866997.
  5. Carson CC, Rajfer J, Eardley I, Carrier S, Denne JS, Walker DJ, Shen W, Cordell WH. The efficacy and safety of tadalafil: an update. BJU Int. 2004 Jun;93(9):1276-81. doi: 10.1111/j.1464-410X.2004.04819.x. PMID: 15180622.
  6. Skoumal R, Chen J, Kula K, Breza J, Calomfirescu N, Basson BR, Kopernicky V. Efficacy and treatment satisfaction with on-demand tadalafil (Cialis) in men with erectile dysfunction. Eur Urol. 2004 Sep;46(3):362-9; discussion 369. doi: 10.1016/j.eururo.2004.04.026. PMID: 15306109.
  7. Montorsi F, Verheyden B, Meuleman E, Jünemann KP, Moncada I, Valiquette L, Casabé A, Pacheco C, Denne J, Knight J, Segal S, Watkins VS. Long-term safety and tolerability of tadalafil in the treatment of erectile dysfunction. Eur Urol. 2004 Mar;45(3):339-44; discussion 344-5. doi: 10.1016/j.eururo.2003.11.010. PMID: 15036680.
  8. Washington SL 3rd, Shindel AW. A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacy. Drug Des Devel Ther. 2010;4:159-171. Published 2010 Sep 7. doi:10.2147/dddt.s9067.
  9. Ali ST. Effectiveness of sildenafil citrate (Viagra) and tadalafil (Cialis) on sexual responses in Saudi men with erectile dysfunction in routine clinical practice. Pak J Pharm Sci. 2008 Jul;21(3):275-81. PMID: 18614424.
  10. Karabakan M, Keskin E, Akdemir S, Bozkurt A. Effect of tadalafil 5mg daily treatment on the ejaculatory times, lower urinary tract symptoms and erectile function in patients with erectile dysfunction. Int Braz J Urol. 2017;43(2):317-324. doi:10.1590/S1677-5538.IBJU.2016.0376.
  11. Sharlip ID, Shumaker BP, Hakim LS, Goldfischer E, Natanegara F, Wong DG. Tadalafil is efficacious and well tolerated in the treatment of erectile dysfunction (ED) in men over 65 years of age: results from Multiple Observations in Men with ED in National Tadalafil Study in the United States. J Sex Med. 2008 Mar;5(3):716-25. doi: 10.1111/j.1743-6109.2007.00712.x. PMID: 18304286.
  12. Giuliano F, Oelke M, Jungwirth A, Hatzimouratidis K, Watts S, Cox D, Viktrup L. Tadalafil once daily improves ejaculatory function, erectile function, and sexual satisfaction in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia and erectile dysfunction: results from a randomized, placebo- and tamsulosin-controlled, 12-week double-blind study. J Sex Med. 2013 Mar;10(3):857-65. doi: 10.1111/jsm.12039. Epub 2013 Jan 24. PMID: 23346990.
  13. Cui H, Liu B, Song Z, Fang J, Deng Y, Zhang S, Wang H, Wang Z. Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia. 2015 Feb;47(1):20-4. doi: 10.1111/and.12216. Epub 2014 Jan 6. PMID: 24387078.
  14. McMahon CG, Carson CC, Fischer CJ, Wang WC, Florio VA, Bradley JD. Tolerance to the therapeutic effect of tadalafil does not occur during 6 months of treatment: A randomized, double-blind, placebo-controlled study in men with erectile dysfunction. J Sex Med. 2006 May;3(3):504-11. doi: 10.1111/j.1743-6109.2006.00248.x. PMID: 16681476.
  15. Jiang H, Zhao LM, Lin HC, et al. Evaluation of the long-term safety and effectiveness of tadalafil once daily in Chinese men with erectile dysfunction: interim results of a multicenter, randomized, open-label trial. Asian J Androl. 2018;20(6):587-592. doi:10.4103/aja.aja_47_18.
  16. Gong B, Ma M, Xie W, Yang X, Huang Y, Sun T, Luo Y, Huang J. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. Int Urol Nephrol. 2017 Oct;49(10):1731-1740. doi: 10.1007/s11255-017-1644-5. Epub 2017 Jul 24. PMID: 28741090; PMCID: PMC5603624.
  17. Hatzimouratidis K. A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction. Ther Adv Urol. 2014 Aug;6(4):135-47. doi: 10.1177/1756287214531639. PMID: 25083163; PMCID: PMC4054509.
  18. McMahon CN, Smith CJ, Shabsigh R. Treating erectile dysfunction when PDE5 inhibitors fail. BMJ. 2006;332(7541):589-592. doi:10.1136/bmj.332.7541.589.
  19. Smith-Harrison LI, Patel A, Smith RP. The devil is in the details: an analysis of the subtleties between phosphodiesterase inhibitors for erectile dysfunction. Transl Androl Urol. 2016;5(2):181-186. doi:10.21037/tau.2016.03.01.
  20. Porst H. IC351 (tadalafil, Cialis): update on clinical experience. Int J Impot Res. 2002 Feb;14 Suppl 1:S57-64. doi: 10.1038/sj.ijir.3900807. PMID: 11850737.
  21. Kim ED, Seftel AD, Goldfischer ER, Ni X, Burns PR. A return to normal erectile function with tadalafil once daily after an incomplete response to as-needed PDE5 inhibitor therapy. J Sex Med. 2014 Mar;11(3):820-30. doi: 10.1111/jsm.12253. Epub 2013 Jul 10. PMID: 23841532.
  22. Porst H, Brock GB, Kula K, Moncada I, Montorsi F, Basson BR, Kinchen K, Aversa A. Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors. J Androl. 2012 Nov-Dec;33(6):1305-22. doi: 10.2164/jandrol.111.015289. Epub 2012 Jul 12. PMID: 22790642.
  23. Segraves RT, Lee J, Stevenson R, Walker DJ, Wang WC, Dickson RA. Tadalafil for treatment of erectile dysfunction in men on antidepressants. J Clin Psychopharmacol. 2007 Feb;27(1):62-6. doi: 10.1097/jcp.0b013e31802e2d60. PMID: 17224715.
  24. Brock G, Montorsi F, Costa P, Shah N, Martinez-Jabaloyas JM, Hammerer P, Ludovico GM, Lee JC, Henneges C, Hamidi K, Rossi A, Mulhall J, Büttner H. Effect of Tadalafil Once Daily on Penile Length Loss and Morning Erections in Patients After Bilateral Nerve-sparing Radical Prostatectomy: Results From a Randomized Controlled Trial. Urology. 2015 May;85(5):1090-1096. doi: 10.1016/j.urology.2014.11.058. Epub 2015 Mar 24. PMID: 25813656.
  25. Giuliano F, Sanchez-Ramos A, Löchner-Ernst D, Del Popolo G, Cruz N, Leriche A, Lombardi G, Reichert S, Dahl P, Elion-Mboussa A, Casariego J. Efficacy and safety of tadalafil in men with erectile dysfunction following spinal cord injury. Arch Neurol. 2007 Nov;64(11):1584-92. doi: 10.1001/archneur.64.11.nct70001. Epub 2007 Sep 10. PMID: 17846260.
  26. Greco EA, Pili M, Bruzziches R, Corona G, Spera G, Aversa A. Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study. J Sex Med. 2006 Jul;3(4):716-722. doi: 10.1111/j.1743-6109.2006.00264.x. PMID: 16839328.
  27. Tavukçu HH, Sener TE, Tinay I, Akbal C, Erşahin M, Cevik O, Cadirci S, Reiter RJ, Sener G. Melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats. Clin Exp Pharmacol Physiol. 2014 Apr;41(4):309-16. doi: 10.1111/1440-1681.12216. PMID: 24552354.
  28. Liu Y. [Cardiovascular-protective effect of tadalafil in the treatment of erectile dysfunction]. Zhonghua Nan Ke Xue. 2013 Dec;19(12):1147-51. Chinese. PMID: 24432631.
  29. Kloner RA, Mitchell M, Emmick JT. Cardiovascular effects of tadalafil. Am J Cardiol. 2003 Nov 6;92(9A):37M-46M. doi: 10.1016/s0002-9149(03)00074-2. PMID: 14609622.
  30. Available at https://link.springer.com/article/10.1007/s11010-020-03710-0.
  31. Salloum FN, Chau VQ, Hoke NN, Kukreja RC. Tadalafil prevents acute heart failure with reduced ejection fraction in mice. Cardiovasc Drugs Ther. 2014 Dec;28(6):493-500. doi: 10.1007/s10557-014-6559-0. PMID: 25322707.
  32. Available at https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.31.1_supplement.1070.2.
  33. Available at https://www.journal-of-cardiology.com/article/S0914-5087(13)00135-4/fulltext.
  34. Groeneweg G, Huygen FJ, Niehof SP, et al. Effect of tadalafil on blood flow, pain, and function in chronic cold complex regional pain syndrome: a randomized controlled trial. BMC Musculoskelet Disord. 2008;9:143. Published 2008 Oct 20. doi:10.1186/1471-2474-9-143.
  35. Kim, Kyu Shik MD, PhDa; Jeong, Tae Yoong MD, PhDb; Moon, Hong Sang MD, PhDa,∗ Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms, Medicine: June 05, 2020 – Volume 99 – Issue 23 – p e20546 doi: 10.1097/MD.0000000000020546.
  36. Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/.
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