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Coenzyme Q10

Coenzyme Q10

Coenzyme Q10 (sometimes called CoQ10) is a unique and important vitamin-like nutrient. It’s produced throughout the body, where it exists in two forms:

  • Ubiquinone, the oxidized form
  • Ubiquinol, the reduced (used) form

Coenzyme Q10 is a crucial cofactor in chemical reactions that are critical for human survival. It helps ensure proper energy production and utilization, fights damaging free radicals, aids in the function of various enzymes, and protects against a broad range of diseases.

How Coenzyme Q10 Works

CoQ10 is a potent antioxidant, which means that it protects cells from damaging free radicals. It is also involved in a wide array of metabolic functions necessary for human survival.

Overall Health Benefits of Coenzyme Q10

  • Increases energy levels [1-4]
  • Prevents and treats cardiovascular disease [5-20]
  • Improves cognitive function [21-33]
  • Lowers blood pressure [34-39]
  • Treats migraine [40-47]
  • Protects against hearing loss [48-54]
  • Improves sexual function [55-57]

Proven Health Benefits of Coenzyme Q10

Increases Energy Levels

Studies show that CoQ10 can help boost your energy levels:

  1. CoQ10 plays a role in the conversion of raw energy from fats and carbohydrates into adenosine triphosphate (ATP), which serves as a fuel needed by all cells in the body to perform at optimal levels. [1]
  2. In animal models of neurodegenerative disease, CoQ10 induced energy repletion. [2]
  3. In trained and untrained individuals, CoQ10 supplementation improved exercise performance. [3]
  4. In broiler chicks fed with CoQ10, a higher production performance was observed. [4]

Prevents and Treats Cardiovascular Disease

A convincing body of evidence shows that CoQ10 is essential for heart health:

  1. In patients with chronic heart failure who took CoQ10 at a dose of 100 mg daily, improvements in symptoms and relief from the condition with no adverse side effects were observed. [5]
  2. In patients with chronic heart failure, researchers found that doses ranging from 60 to 200 mg/day given at 1 to 6 months were able to significantly enhance blood flow to the heart. [6]
  3. Several clinical trials found that coenzyme Q10 can be used as an additional treatment for patients receiving standard therapy for heart disease. [7-8]
  4. A review of several studies also found that CoQ10 supplement may be a useful tool for managing patients with heart failure. [9]
  5. In patients with recent myocardial infarction, CoQ10 reduced the risk of atherosclerosis (abnormal plaque formation within the heart arteries) by decreasing total and low density lipoprotein cholesterol. [10-11]
  6. In patients with heart failure, CoQ10 reduced the incidence of major adverse cardiovascular event. [12-13]
  7. In dogs with experimental congestive heart failure, CoQ10 decreased the severity of the disease. [14]
  8. In children with heart failure, CoQ10 reduced the incidence of deaths associated with the disease. [15]
  9. In patients with heart failure who used CoQ10, a lower death rate and higher exercise capacity were observed compared with placebo-treated patients. [16]
  10. In patients with chronic heart failure, oral CoQ10 supplementation resulted in improvement in heart function. [17]
  11. In elderly citizens, CoQ10 supplementation for 4 years reduced death rate associated with heart disease. [18]
  12. In patients with chronic heart failure, CoQ10 supplementation was associated with a lower risk of death and hospitalization rate. [19]
  13. In patients with acute myocardial infarction, CoQ10 reduced the incidence of heart attack by preventing adhesion of cells. [20]

Improves Cognitive Function

Several lines of evidence suggest that CoQ10 can help combat cognitive decline caused by aging and brain disorders:

  1. In patients with Parkinson’s disease, administration of CoQ10 at dosages of up to 1200 mg per day slowed the progressive deterioration of bodily functions without any adverse side effects. [21-22]
  2. In a Japanese general population, low levels of CoQ10 have been associated with higher risk of dementia. [23]
  3. In healthy elderly subjects, CoQ10 supplementation ameliorated cognitive decline. [24]
  4. In patients undergoing hemodialysis, daily intake of CoQ10 at 100 mg improved cognitive status. [25]
  5. In a mouse model of Alzheimer’s disease, CoQ10 administration decreased the levels of abnormal proteins in the brain. [26]
  6. In rats with phenytoin-induced cognitive impairment, CoQ10 administration improved performance in behavioral tests. [27]
  7. In dogs, low levels of CoQ10 in the brain have been found to cause cognitive impairment. [28]
  8. In rats, CoQ10 ameliorated phenytoin-induced cognitive impairment and oxidative stress. [29]
  9. In diabetic middle-aged rats, CoQ10 supplementation improved learning and memory. [30]
  10. In rats, the combination of CoQ10 and antioxidants improved memory and brain cell viability. [31]
  11. In old rats, CoQ10 protected brain cells against injury or damage. [32]
  12. In young mice, CoQ10 reduced sevoflurane-induced cognitive deficiency. [33]

Lowers Blood Pressure

Studies show that CoQ10 has blood pressure-lowering effects:

  1. A review of several clinical trials found that CoQ10 supplementation significantly decreased systolic blood pressure. [34]
  2. In hypertensive patients, CoQ10 supplementation lowered systolic and diastolic blood pressure without any side effects. [35-36]
  3. In patients with primary hypertension, CoQ10 supplementation reduced blood pressure after 3 weeks. [37]
  4. A study found that CoQ10 lowers blood pressure by relaxing the blood vessels. [38]
  5. When administered together with antihypertensive medications, CoQ10 can significantly reduce blood pressure. [39]

Treats Migraine

Numerous studies also support the beneficial effects of CoQ10 on migraine:

  1. In patients with migraine attacks per month, CoQ10 supplementation reduced migraine days. [40]
  2. In migraine patients, CoQ10 supplementation reduced migraine frequency, headache-days and days-with-nausea. [41]
  3. In patients with migraine, CoQ10 administration at a dose of 150 mg per day resulted in greater than 50% reduction in the number of days with migraine headache. [42-43]
  4. In patients with migraine, CoQ10 reduced migraine attacks by decreasing the levels of inflammatory substances. [44]
  5. A study found that CoQ10 deficiency was associated with pediatric and adolescent migraine. [45]
  6. When combined with magnesium and riboflavin, CoQ10 significantly reduced the frequency of migraines. [46]
  7. A study found that CoQ10 is a safe and effective therapy for migraine prophylaxis. [47]

Protects Against Hearing Loss

Sensorineural hearing loss, a condition that is characterized by damage to the sensory hearing organ, is not correctable through medical interventions. Interestingly, studies found that CoQ10 has the potential to treat and protect against this ear condition:

  1. In patients with sensorineural hearing loss, CoQ10 supplementation was able to prevent further hearing loss. [48]
  2. In animal models of sensorineural hearing loss due to low oxygen levels, CoQ10 promoted recovery from damage in auditory hair cells (modulates sound frequency and tone). [49]
  3. In guinea pigs with noise-induced hearing loss, CoQ10 supplementation was associated with lower hair cell damage. [50]
  4. When combined with steroid therapy, CoQ10 produced beneficial effects in the treatment of sudden sensorineural hearing loss. [51]
  5. In mice, CoQ10 protected hair cells against aminoglycoside-induced hearing loss. [52]
  6. In patients with maternally inherited diabetes mellitus and deafness, CoQ10 therapy prevented progressive hearing loss. [53]
  7. In patients with noise-induced hearing loss, CoQ10 for 30 days accelerated the recovery process. [54]

Improves Sexual Function

Numerous studies show that CoQ10 may help ramp up sexual power in men:

  1. In patients with early chronic Peyronie’s disease (scar or plaque formation inside the penis that causes curved, painful erections) CoQ10 supplementation at a dose of 300 mg for 24 weeks resulted in significant reduction in plaque size and penile curvature as well as improvement in erectile function. [55]
  2. A study found that CoQ10 may help increase libido by increasing the levels of the hormone testosterone. [56]
  3. In men with low sperm count, Q10 supplementation at 400 mg per day improved semen parameters and antioxidant status. [57]

References:

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