Delta Sleep-Inducing Peptide

Overall Health Benefits

• Improves sleep quality [1-7]
• Lowers risk of heart disease [8-11]
• Lowers blood pressure [12-13]
• Prevents cancer [14-15]
• Boosts brain power [16-22]
• Treats symptoms of diabetes [23-25]
• Fights stress [26-33]

Proven Health Benefits

Improves Sleep Quality

A number of studies support the beneficial effects of DSIP on sleep quality and quantity:

1. A study showed that DSIP can stimulate sleep in disturbed human sleep pattern. [1]
2. In patients with insomnia, DSIP injection resulted in longer sleep duration with reduced interruptions. [2-3]
3. In cats, a single injection of DSIP effectively shortened sleep latency and significantly increased the total sleep duration. [4]
4. A review of several studies showed that DSIP is effective in inducing delta sleep (deep stage of sleep) in rabbits, rats, mice, cats, and humans. [5]
5. A study showed that high-dose administration of DSIP was associated with improvements in symptoms of insomnia. [6]
6. In healthy individuals, DSIP was effective in inducing sleep without any side effects. [7]

Lowers Risk of Heart Disease

Studies suggest that DSIP also has cardioprotective effects:

1. In rabbits, DSIP administration corrected abnormal heart rhythm. [8]
2. In rats and rabbits, DSIP restored normal heart rhythm during the occurrence of emotional stress. [9]
3. In animal models, DSIP injection reduced abnormally fast heart rate. [10]
4. In male rabbits, DSIP improved blood flow via direct actions on heart function. [11]

Lowers Blood Pressure

There are also studies supporting the anti-hypertensive effects of DSIP:

1. In spontaneously hypertensive rats (SHR), subcutaneous injection of DSIP significantly reduced the blood pressure of the subjects. [12]
2. Administration of DSIP in hypertensive rats at 200 μg kg daily for 10 days lowered blood pressure. [13]

Prevents Cancer

Evidence also suggests that DSIP possesses anti-cancer properties:

1. In hypertensive rats, DSIP treatment was associated with a lower risk of tumor growth. [14]
2. A study showed that DSIP can enhance the effects of chemotherapeutic drugs while reducing its unwanted side effects. [15]

Boosts Brain Power

DSIP is not only vital for sleep but also for brain health:

1. In rats, DSIP injections significantly increased their resistance against acute emotional stress. [16]
2. A study showed that the stress-protective effects of DSIP can be attributed to its antioxidant properties. [17]
3. In rats with cerebral ischemia (low blood supply in the brain), DSIP administration resulted in increased blood supply and higher survival rate. [18]
4. In adult male rats, DSIP administration greatly reduced the occurrence, duration, and severity of seizures, suggesting that it is a suitable antiepileptic drug. [19-20]
5. In animals with cerebral ischemia, DSIP reduced the severity and lethality of the condition. [21]
6. In rats, the improved sleep quality from DSIP injection further resulted in the restoration of spatial memory. [22]

Treats Symptoms of Diabetes

DSIP has also been shown to have beneficial effects on symptoms of diabetes:

1. In elderly diabetic patients, a daily dose of DSIP improved quality of life and reduced mood depression and emotional lability. [23]
2. In diabetic patients with eye complications, daily dose of 0.0003 g of DSIP intranasally for two months improved visual function. [24-25]

Fights Stress

Evidence shows that DSIP can help fight stress:

1. In animal models of stress, DSIP administration reduced behaviors associated with stress. [26-27]
2. In rats, DSIP injections significantly increased acute emotional stress resistance. [28]
3. In rats treated with chlorpromazine-morphine-pentobarbital, DSIP administration significantly reduced the levels of the stress hormone cortisol. [29-30]
4. In rats, higher levels of DSIP were associated with more resistance against emotional stress. [31-33]

References:

1. Lyle H. Miller, Barry A. Turnbull, Abba J. Kastin, David H. Coy, Sleep-Wave Activity of a Delta Sleep-Inducing Peptide Analog Correlates with its Penetrance of the Blood-Brain Barrier, Sleep, Volume 9, Issue 1, March 1986, Pages 80–84, https://doi.org/10.1093/sleep/9.1.80.
2. Schneider-Helmert D, Schoenenberger GA. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia. 1981;37(9):913-7. doi: 10.1007/BF01971753. PMID: 7028502.
3. Bes F, Hofman W, Schuur J, Van Boxtel C. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology. 1992;26(4):193-7. doi: 10.1159/000118919. PMID: 1299794.
4. Susić V, Masirević G, Totić S. The effects of delta-sleep-inducing peptide (DSIP) on wakefulness and sleep patterns in the cat. Brain Res. 1987 Jun 30;414(2):262-70. doi: 10.1016/0006-8993(87)90006-0. PMID: 3620931.
5. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984 Spring;8(1):83-93. doi: 10.1016/0149-7634(84)90022-8. PMID: 6145137.
6. Schneider-Helmert D. DSIP in insomnia. Eur Neurol. 1984;23(5):358-63. doi: 10.1159/000115714. PMID: 6391925.
7. Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA. Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. Int J Clin Pharmacol Ther Toxicol. 1981 Aug;19(8):341-5. PMID: 6895513.
8. Zviaginsteva MA. Rol’ peptida delta-sna v élektricheskoĭ stabil’nosti serdtsa [The role of delta sleep-inducing peptide in the electric stability of the heart]. Kardiologiia. 1988 Mar;28(3):89-91. Russian. PMID: 3379896.
9. Ul’ianinskiĭ LS, Ivanov VT, Mikhaleva II, Sudakov KV. Peptid del’ta-sna kak moduliator serdechnoĭ deiatel’nosti: teoreticheskie rekomendatsii dlia praktiki [Delta-sleep peptide as a modulator of cardiac activity: theoretical recommendations for practice]. Kosm Biol Aviakosm Med. 1990 May-Jun;24(3):23-8. Russian. PMID: 2197498.
10. Zviagintseva MA, Kosharskaia IL, Ul’ianinskiĭ LS. Vliianie peptida del’ta-sna na parasimpaticheskuiu reguliatsiiu serdechnogo ritma [Effect of the delta-sleep peptide on parasympathetic regulation of the cardiac rhythm]. Biull Eksp Biol Med. 1986 Apr;101(4):390-1. Russian. PMID: 3754472.
11. Pimenova TI. Gemodinamika pri deĭstvii peptida del’ta-sna [Hemodynamics as affected by delta-sleep-inducing peptide]. Patol Fiziol Eksp Ter. 1991;(6):16-8. Russian. PMID: 1818276.
12. Graf MV, Kastin AJ, Schoenenberger GA. Delta sleep-inducing peptide in spontaneously hypertensive rats. Pharmacol Biochem Behav. 1986 Jun;24(6):1797-9. doi: 10.1016/0091-3057(86)90524-1. PMID: 3755534.
13. Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003 Jun;124(6):721-31. doi: 10.1016/s0047-6374(03)00082-4. PMID: 12782416.
14. Graf MV, Kastin AJ, Schoenenberger GA. Delta sleep- inducing peptide in spontaneously hypertensive rats. Pharmacol Biochem Behav 1986; 24: 1797–1799.
15. Mikhaleva II, Ivanov VT, Onoprienko LV, Prudchenko IA, Chikin LD, Yakubovskaya RI, Nemtsova ER, Bezborodova OA. [Antioxidative and detoxifying effects of analogues of delta-sleep inducing peptide (DSIP)]. Bioorg Khim. 2014 Jan-Feb;40(1):3-11. Russian. doi: 10.1134/s1068162014010087. PMID: 25898718.
16. Sudakov, K.V., Ivanov, V.T., Koplik, E.V. et al. Delta-sleep-inducing peptide (DSIP) as a factor facilitating animals’ resistance to acute emotional stress. Pav. J. Biol. Sci. 18, 1–5 (1983). https://doi.org/10.1007/BF03004904.
17. Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003 Feb;24(2):307-11. doi: 10.1016/s0196-9781(03)00040-8. PMID: 12668217.
18. Koplik EV, Umryukhin PE, Konorova IL, Terekhina OL, Mikhaleva II, Gannushkina IV, Sudakov KV. Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection. Neurosci Behav Physiol. 2008 Nov;38(9):953-7. doi: 10.1007/s11055-008-9076-4. PMID: 18975104.
19. Stanojlovic O, Zivanovic D, Susic V. Delta-peptid spavanja i njegov uticaj na elektroencefalogram i spektralnu gustinu snage kod pacova s metafitskom epilepsijom [The delta-sleep inducing peptide and its effect on the electroencephalogram and power spectrum density in rats with metaphit-induced epilepsy]. Srp Arh Celok Lek. 2001 May-Jun;129(5-6):114-8. Serbian. PMID: 11797457.
20. Shandra AA, Godlevskii LS, Brusentsov AI, Petrashevich VP, Vast’yanov RS, Nikel B, Mikhaleva II. Delta-sleep-inducing peptide and its analogs and the serotoninergic system in the development of anticonvulsive influences. Neurosci Behav Physiol. 1998 Sep-Oct;28(5):521-6. doi: 10.1007/BF02463012. PMID: 9809291.
21. Shandra AA, Godlevskii LS, Brusentsov AI, Vast’yanov RS, Karlyuga VA, Dzygal AF, Nikel B. Effects of delta-sleep-inducing peptide in cerebral ischemia in rats. Neurosci Behav Physiol. 1998 Jul-Aug;28(4):443-6. doi: 10.1007/BF02464804. PMID: 9762721.
22. Roy K, Chauhan G, Kumari P, Wadhwa M, Alam S, Ray K, Panjwani U, Kishore K. Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude. Life Sci. 2018 Sep 15;209:282-290. doi: 10.1016/j.lfs.2018.08.026. Epub 2018 Aug 11. PMID: 30107169.
23. Odin VI, Belikova TV, Pushkova ES, Barr NA. Sakharnyĭ diabet u pozhilykh: geroprotektivnye i protivodiabeticheskie svoĭstva preparata del’ta-son indutsiruiushchego peptida [Diabetes mellitus in elderly: geroprotective and antidiabetic properties of delta-sleep induced peptide]. Adv Gerontol. 2004;15:101-14. Russian. PMID: 15754961.
24. Kresiun NV, Godlevskiĭ LS. [Using deltalicin for the treatment of patients with diabetic retinopathy]. Eksp Klin Farmakol. 2014;77(12):22-5. Russian. PMID: 25739189.
25. Kresyun NV. The influence of deltalycyn and transcranial cerebellar stimulation upon recovery of retina after photo stress in patients with diabetic retinopathy. Rev Med Chir Soc Med Nat Iasi. 2014 Oct-Dec;118(4):1068-73. PMID: 25581971.
26. Graf MV, Schoenenberger GA. Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. J Neurochem. 1987 Apr;48(4):1252-7. doi: 10.1111/j.1471-4159.1987.tb05654.x. PMID: 3029331.
27. Miller LH, Turnbull BA, Kastin AJ, Coy DH. Sleep-wave activity of a delta sleep-inducing peptide analog correlates with its penetrance of the blood-brain barrier. Sleep. 1986;9(1):80-4. doi: 10.1093/sleep/9.1.80. PMID: 3754348.
28. Salieva RM, Ianovskiĭ K, Ratsak R, Trofimova IaI, Oehme P, Sudakov KV, Iumatov EA. Peptid, vyzyvaiushchiĭ del’ta-son, kak faktor, povyshaiushchiĭ soderzhanie veshchestva P v gipotalamuse i ustoĭchivost’ krys k émotsional’nomu stressu [The delta sleep-inducing peptide as a factor enhancing the content of substance P in the hypothalamus and the resistance of rats to emotional stress]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1991 May-Jun;41(3):558-63. Russian. PMID: 1718095.
29. Sudakov KV, Ivanov VT, Koplik EV, Vedjaev DF, Michaleva II, Sargsjan AS. Delta-sleep-inducing peptide (DSIP) as a factor facilitating animals’ resistance to acute emotional stress. Pavlov J Biol Sci. 1983 Jan-Mar;18(1):1-5. doi: 10.1007/BF03004904. PMID: 6687936.
30. Graf MV, Kastin AJ, Coy DH, Fischman AJ. Delta-sleep-inducing peptide reduces CRF-induced corticosterone release. Neuroendocrinology. 1985 Oct;41(4):353-6. doi: 10.1159/000124200. PMID: 2995861.
31. Bondarenko TI, Milyutina NP, Shustanova TA, Mikhaleva II. The effects of delta sleep-inducing peptide on the intensity of lipid peroxidation and xanthine oxidase activity in rat tissues during cold stress. Neurosci Behav Physiol. 2001 Jan-Feb;31(1):83-6. doi: 10.1023/a:1026686516768. PMID: 11265821.
32. Salieva RM, Koplik EV, Kamenov ZA, Poletaev AB. Vliianie beta-éndorfina i peptida, vyzyvaiushchego del’ta-son, na ustoĭchivost’ k émotional’nomu stressu [Effects of beta endorphin and delta-sleep inducing peptide on resistance to emotional stress]. Biull Eksp Biol Med. 1989 Oct;108(10):464-6. Russian. PMID: 2532045.
33. Salieva RM, Koplik EV, Kamenov ZA, Poletaev AB. Peptid, vyzyvaiushchiĭ del’ta-son, v krovi i gipotalamuse u krys s razlichnoĭ ustoĭchivost’iu k émotsional’nomu stressu [Delta sleep-inducing peptide in the blood and hypothalamus of rats with various resistance to emotional stress]. Biull Eksp Biol Med. 1988 Sep;106(9):264-6. Russian. PMID: 3167172.