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Primobolan Side Effects and Medical Indications
Wednesday, August 14th, 2019

Primobolan is an anabolic steroid that is used to increase muscle mass and strength, reduce body fat percentage, enhance sports performance, and improve cognition. This powerful nootropic is made from dihydrotestosterone, a hormone which is the active form of testosterone and plays a major role in muscle and bone development, sex drive, and other important biological functions. To reap the full anabolic benefits of Primobolan, you can take it in the form of tablets (ethyl Primobolan or Methenolone acetate) or injections (Primobolan Depot or Methenolone enanthate).

What are the Side Effects Primobolan?

Almost all anabolic steroids carry aftereffects. However, Primobolan’s side effects are very mild and tolerable especially with responsible use. The following are the known side effects of Primobolan:

  1. Androgenic: Aside from increased muscle mass and strength, androgenic effects of Primobolan include mild acne, oily skin, and body hair growth. For people who have a genetic predisposition for acne, they may develop the condition while on Primobolan. On the other hand, people without genetic predisposition may not develop acne while taking Primobolan.
  2. Testosterone: All anabolic steroids suppress the natural production of the male hormone testosterone up to various extents. However, the rate at which an anabolic steroid suppress testosterone production depends on the type and dosage of the steroid. Unlike other steroids, Primobolan has mild effects on testosterone level, thus preventing them from falling below normal.
  3. Cardiovascular: Primobolan has no negative effect on blood pressure in most healthy adults. However, Primobolan can slightly reduce the levels of high-density lipoprotein (good cholesterol) but this suppression is not significant enough to cause abnormally low levels. In addition, any good cholesterol that is lost while on Primobolan can be easily replaced by consuming a diet rich in omega fatty acids and low in saturated fats and simple sugars.
  4. Hepatic: Oral Primobolan is not toxic to the liver. In fact, a study found that Methenolone enanthate administration in patients with liver cirrhosis has beneficial effects on liver function by increasing the turnover of albumin,[1] a type of protein that prevents fluid from leaking out of blood vessels. Therefore, the hepatic side effect of Primobolan is increased albumin metabolism.
  5. Reproductive: Primobolan and other anabolic steroids can increase libido especially if prescribed at low dosages. [2]In men, side effect can include harder and longer penile erections as Methenolone enanthate increases the levels of nitric oxide,[3] a substance that improves blood circulation by relaxing blood vessels.
  6. Hematological: Hematological side effect of Primobolan includes increased production of red blood cells (erythropoiesis).[4] Because of this beneficial effect, Primobolan is prescribed for various hematological conditions such as anemia.

What are the Medical Indications for Primobolan Use?

Aside from bodybuilding and weight loss, Primobolan is also an effective therapeutic option for various medical conditions.

Anemia

Anemia is a condition characterized by low levels of red blood cells or hemoglobin. Interestingly, studies show that Primobolan can benefit different types of anemia by improving hematological parameters as well as symptoms.

A study by Krug found that Methenolone enanthate administration in patients with aplastic anemia, a deficiency of all types of blood cells, may help prevent disease remission.[5] Although there was partial remission in some patients, most of them reported relief from symptoms. Other studies were also consistent with this result and suggest that Methenolone enanthate administration at 1–3 mg/kg per day may improve anemic symptoms dramatically.[6] [7]

In another study, Shimoda and colleagues reported that Primobolan administration in patients with anemia caused by myelofibrosis, a serious bone marrow disorder that affects the normal production of blood cells, may help treat the disease by increasing hemoglobin levels.[8] Researchers observed that patients who received the treatment had reduced number of blood transfusions because they have improved hematological parameters.

Finally, a study by Uozumi and colleagues found that Primobolan administration may help treat anemia by increasing the production of red blood cells.[9] Researchers found that patients with pure red cell aplasia (PRCA), a condition in which the bone marrow ceases to produce red blood cells, who received Primobolan had increased red blood cells and reported lesser symptoms.

Muscle Wasting

Primobolan is usually prescribed for patients with muscle wasting caused by chronic medical conditions or the aging process. Whatever the cause is, studies show that this anabolic steroid has the capacity to increase muscle mass and strength.

In one study, Dardenne and colleagues reported that Methenolone enanthate administration in patients with age-related degeneration of tissues and organs (senile involution) prevented further decrease in muscle mass.[10] This result suggests that the treatment may help prevent age-related muscle wasting.

Okamoto and colleagues also found that Methenolone enanthate administration at a dose of 100 mg injected intramuscularly weekly for 6 weeks in patients with paralysis of one side of the body (hemiplegia) improved muscle cross-sectional area (CSA) of the thigh.[11]

Furthermore, a study by Litchfield found that administration of Methenolone acetate in underweight and premature patients increased weight and muscle mass.[12] This result suggests that Primobolan may help treat muscle wasting associated with birth and malnutrition.

Burn Injury

Primobolan is also indicated for burn injury because of its regenerative properties. Evidence shows that this anabolic steroid may speed up the wound healing phase.

Lagrot and colleagues investigated the effects of Methenolone enanthate on patients with burn injuries.[13] Researchers observed that the treatment led to faster wound healing and lesser scarring. This result suggests that the treatment may be beneficial especially in the acute phase of burn injury.

Osteoporosis

Osteoporosis can increase one’s risk of fractures and falls. Interestingly, Primobolan exerts bone-boosting properties that can combat different bone conditions.

In one study, Frankle and colleagues reported that Methenolone enanthate administration at a dose of 4mg/kg in rats with fracture increased the concentration of calcium in the injured area.[14] This observation is indicative of improved bone healing.

In another study, Almustafa and colleagues reported that the combination of calcium and Primobolan may significantly lower fracture rate.[15] The data of the study showed that both postmenopausal and nonmenopausal women who received the combined treatment had lower fracture rate scores.

References:

  1. Knöbel H, Becker K. [Effect of an anabolic steroid (methenolone enanthate) on the intra- and extravasal albumin pool in liver cirrhosis]. Z Gastroenterol. 1975;13(6):583-7.
  2. Armstrong JM, Avant RA, Charchenko CM, et al. Impact of anabolic androgenic steroids on sexual function. Transl Androl Urol. 2018;7(3):483–489. doi:10.21037/tau.2018.04.23
  3. Arazi H, Mohammadjafari H, Asadi A. Use of anabolic androgenic steroids produces greater oxidative stress responses to resistance exercise in strength-trained men. Toxicol Rep. 2017;4:282–286. Published 2017 Jun 8. doi:10.1016/j.toxrep.2017.05.005
  4. Shimoda K, Shide K, Kamezaki K, et al. The effect of anabolic steroids on anemia in myelofibrosis with myeloid metaplasia: retrospective analysis of 39 patients in Japan. Int J Hematol. 2007;85(4):338-43.
  5. Krug K. [Pathophysiology of aplastic anemia and its treatment with methenolone enanthate]. Z Gesamte Inn Med. 1980;35(22):809-12.
  6. Available from https://drugs.ncats.io/drug/9062ZT8Q5C#publications.
  7. Urabe A, Ichiki S, Usukine K, Ijima K. [Treatment of adult patients with aplastic anemia in Japan]. Rinsho Ketsueki. 2005;46(6):389-93.
  8. Shimoda K, Shide K, Kamezaki K, et al. The effect of anabolic steroids on anemia in myelofibrosis with myeloid metaplasia: retrospective analysis of 39 patients in Japan. Int J Hematol. 2007;85(4):338-43.
  9. Uozumi K, Makino T, Kuwazuru Y, et al. [Pure red cell aplasia (PRCA) with T-cell lymphocytosis successfully treated with cyclophosphamide and metenolone]. Rinsho Ketsueki. 1987;28(7):1165-9.
  10. Dardenne P, Cantala P. [TREATMENT OF SENILE INVOLUTION BY AN ANABOLIZING STEROID (METHENOLONE ENANTHATE)]. Toulouse Med. 1964;65:787-96.
  11. Okamoto S, Sonoda S, Tanino G, Tomida K, Okazaki H, Kondo I. Change in thigh muscle cross-sectional area through administration of an anabolic steroid during routine stroke rehabilitation in hemiplegic patients. Am J Phys Med Rehabil. 2011;90(2):106-11.
  12. Litchfield HR. ANABOLIC EFFECTS OF METHENOLONE ENANTHATE AND METHENOLONE ACETATE IN UNDERWEIGHT PREMATURE INFANTS AND CHILDREN. N Y State J Med. 1965;65:645-8.
  13. Lagrot F, Costagliola M, Micheau P, Mansat C. [BURN PATIENTS OVER LONG PERIODS AND THEIR TREATMENT. THE PLACE OF ANABOLIC STEROIDS (METHENOLONE ENANTHATE)]. Bull Mem Soc Chir Paris. 1965;55:129-38.
  14. Frankle M, Borrelli J. The effects of testosterone propionate and methenolone enanthate on the healing of humeral osteotomies in the Wistar rat. J Invest Surg. 1990;3(2):93-113.
  15. Almustafa M, Doyle FH, Gutteridge DH, et al. Effects of treatments by calcium and sex hormones on vertebral fracturing in osteoporosis. Q J Med. 1992;83(300):283-94.
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