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Primobolan
Wednesday, August 14th, 2019

Primobolan is an anabolic steroid that allows users to build lean muscle mass, reduce body fat, enhance athletic performance, and boost cognitive function. This powerful nootropic is available in injectable form (Primobolan Depot or Methenolone enanthate) and in tablet form (ethyl Primobolan or Methenolone acetate). Primobolan is considered one of the safest anabolic steroids available on the market today. In fact, it has been used safely and effectively in the treatment of weight loss in children and premature infants without any adverse side effects. In addition, Primobolan is also prescribed for muscle wasting diseases, malnutrition, and osteoporosis.

Overall Health Benefits of Primobolan

  • Increases Muscle Mass and Strength [1-16]
  • Treats Anemia [17-23]
  • Improves Kidney Function [24-27]
  • Improves Wound and Bone Healing [28-30]

How Primobolan Works?

Primobolan is an anabolic steroid, which means that it aids in increasing muscle mass and strength. This powerful nootropic was created from dihydrotestosterone, a hormone which is the active form of testosterone and plays an integral part in muscle and bone growth. Because of this, Primobolan has improved anabolic nature and potency.

Proven Health Benefits of Primobolan

Increases Muscle Mass and Strength

Just like other anabolic steroids, the primary benefit of Primobolan is focused on increasing muscle mass and strength. There’s a good deal of strong evidence supporting its muscle-boosting properties:

  1. Primobolan speeds up the rate of protein synthesis, resulting in larger and stronger muscles. [1-3]
  2. Primobolan increases muscle mass and strength by binding to androgen receptors in skeletal muscle. [4]
  3. Methenolone enanthate administration in patients with age-related degeneration of tissues and organs (senile involution) prevented further decrease in muscle mass. [5]
  4. In patients with paralysis of one side of the body (hemiplegia), Methenolone enanthate administration (100 mg injected intramuscularly weekly for 6 weeks) improved muscle cross-sectional area (CSA) of the thigh. [6]
  5. In bodybuilders, Primobolan administration increased body size and muscle strength.[7]
  6. Administration of Primobolan for 1 month increased masseter muscle (used for biting and chewing) mass and strength in a patient who regularly use anabolic steroids. [8]
  7. Administration of Methenolone acetate in underweight and premature patients increased weight and muscle mass.[9]
  8. In 8-week-old male Wistar rats, Primobolan administration improved passive repetitive dorsiflexion and plantar flexion of the skeletal muscle of the ankle joint. [10]
  9. In animal models, Primobolan administration stimulated the growth and development of muscles. [11-12]
  10. In animal models, Primobolan administration at 100 mg/week led to an increase in the size of latissimus dorsi (muscles of the lower back). [13-17]
  11. Administration of Methenolone enanthate at 100 mg/week in animals resulted in improvement of muscle fiber type transformation. [16]

Treats Anemia

Primobolan does not only increase muscle mass and strength but it also helps treat anemia, a condition characterized by low levels of red blood cells or hemoglobin. According to studies, this powerful nootropic can benefit different types of anemia:

  1. In patients with aplastic anemia, a deficiency of all types of blood cells, Methenolone enanthate administration prevented disease remission. [17]
  2. In patients with anemia caused by myelofibrosis, a serious bone marrow disorder that affects the normal production of blood cells, Primobolan administration increased hemoglobin levels and reduced the number of blood transfusions. [18]
  3. In adults with aplastic anemia, Primobolan administration at 1–3 mg/kg per day improved anemic symptoms. [19-20]
  4. In patients with anemia caused by myelodysplastic syndrome, a condition that leads to increased numbers of immature blood cells, oral Primobolan administration at 20 mg/kg led to hematological improvement. [21]
  5. In patients with pure red cell aplasia (PRCA), a condition in which the bone marrow ceases to produce red blood cells, Primobolan administration successfully treated the disease. [22]
  6. In patients with leukemia, Primobolan supplementation improved symptoms of the disease. [23]

Improves Kidney Function

This anabolic steroid can also benefit people with existing kidney disease and can lower the risk of kidney problems according to studies:

  1. In patients with wandering kidney (floating kidney), nephritis (kidney inflammation), and nephrosis (degeneration of the kidney tubules), both oral and injectable Primobolan administration led to remarkable improvement in subjective and objective symptoms. [24]
  2. In patients with kidney failure, Primobolan administration increased the production of red blood cells, which is suggestive of improved kidney function. [25]
  3. In male castrated rats, administration of Primobolan improved kidney function. [26]
  4. Administration of Primobolan in aged animals has also been shown to improve the ability of the kidneys to filter wastes and toxins. [27]

Improves Wound and Bone Healing

There is also strong scientific evidence supporting the regenerative properties of Primobolan. Studies show that this potent nootropic can accelerate recovery from injury:

  1. In burn patients, Methenolone enanthate administration led to faster wound healing. [28]
  2. In rats with fracture, administration of Methenolone enanthate at 4mg/kg increased the concentration of calcium in the injured area, which is suggestive of improved bone healing. [29]
  3. A study found that Methenolone enanthate can help speed up regeneration of injured tissues by decreasing the levels of inflammatory markers such as TNF-α. [30]

 

References:

  1. Available from https://www.sciencedirect.com/science/article/pii/S0271531705800636.
  2. Kicman AT. Pharmacology of anabolic steroids. Br J Pharmacol. 2008;154(3):502–521. doi:10.1038/bjp.2008.165.
  3. Kersey RD, Elliot DL, Goldberg L, et al. National Athletic Trainers’ Association position statement: anabolic-androgenic steroids. J Athl Train. 2012;47(5):567–588. doi:10.4085/1062-6050-47.5.08.
  4. Saartok T, Dahlberg E, Gustafsson JA. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology. 1984;114(6):2100-6.
  5. Dardenne P, Cantala P. [TREATMENT OF SENILE INVOLUTION BY AN ANABOLIZING STEROID (METHENOLONE ENANTHATE)]. Toulouse Med. 1964;65:787-96.
  6. Okamoto S, Sonoda S, Tanino G, Tomida K, Okazaki H, Kondo I. Change in thigh muscle cross-sectional area through administration of an anabolic steroid during routine stroke rehabilitation in hemiplegic patients. Am J Phys Med Rehabil. 2011;90(2):106-11.
  7. Skårberg K, Nyberg F, Engström I. The development of multiple drug use among anabolic-androgenic steroid users: six subjective case reports. Subst Abuse Treat Prev Policy. 2008;3:24. Published 2008 Nov 28. doi:10.1186/1747-597X-3-24
  8. Skoura C, Mourouzis C, Saranteas T, Chatzigianni E, Tesseromatis C. Masseteric hypertrophy associated with administration of anabolic steroids and unilateral mastication: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(5):515-8.
  9. Litchfield HR. ANABOLIC EFFECTS OF METHENOLONE ENANTHATE AND METHENOLONE ACETATE IN UNDERWEIGHT PREMATURE INFANTS AND CHILDREN. N Y State J Med. 1965;65:645-8.
  10. Ikeda S, Kamikawa Y, Ohwatashi A, Harada K, Yoshida A. The effect of anabolic steroid administration on passive stretching-induced expression of mechano-growth factor in skeletal muscle. ScientificWorldJournal. 2013;2013:313605.
  11. Joechle W, Langecker H. [Biological effects of 1-methyl-delta1-androsten-17beta-ol-3-one 17-acetate and 17-enanthate (methenolone acetate and methenolone enanthate): growth stimulation, composition of animal body and enzyme metabolism]. Arzneimittelforschung. 1962;12:218-23.
  12. Truckenbrodt H. [Age-related anabolic effect of primobolan in animal experiments]. Monatsschr Kinderheilkd. 1970;118(6):248-50.
  13. Fritzsche D, Krakor R, Asmussen G, et al. Anabolic steroids (metenolone) improve muscle performance and hemodynamic characteristics in cardiomyoplasty. Ann Thorac Surg. 1995;59(4):961-9.
  14. Fritzsche D, Krakor R, Asmussen G, et al. Effect of an anabolic steroid (Metenolon) on contractile performance of the chronically stimulated latissimus dorsi in sheep. Eur J Cardiothorac Surg. 1994;8(4):214-9.
  15. Fritzsche D, Krakor R, Asmussen G, et al. Anabolic steroids (metenolone) improve muscle performance and hemodynamic characteristics in cardiomyoplasty. Ann Thorac Surg. 1995;59(4):961-9.
  16. Czesla M, Mehlhorn G, Fritzsche D, Asmussen G. Cardiomyoplasty – improvement of muscle fibre type transformation by an anabolic steroid (metenolone). J Mol Cell Cardiol. 1997;29(11):2989-96.
  17. Krug K. [Pathophysiology of aplastic anemia and its treatment with methenolone enanthate]. Z Gesamte Inn Med. 1980;35(22):809-12.
  18. Shimoda K, Shide K, Kamezaki K, et al. The effect of anabolic steroids on anemia in myelofibrosis with myeloid metaplasia: retrospective analysis of 39 patients in Japan. Int J Hematol. 2007;85(4):338-43.
  19. Available from https://drugs.ncats.io/drug/9062ZT8Q5C#publications.
  20. Urabe A, Ichiki S, Usukine K, Ijima K. [Treatment of adult patients with aplastic anemia in Japan]. Rinsho Ketsueki. 2005;46(6):389-93.
  21. Hamamoto K, Ohno T, Ogawa H. [Myelodysplastic syndrome with CREST syndrome successfully treated with metenolone–A case report]. Rinsho Ketsueki. 1996;37(4):362-5.
  22. Uozumi K, Makino T, Kuwazuru Y, et al. [Pure red cell aplasia (PRCA) with T-cell lymphocytosis successfully treated with cyclophosphamide and metenolone]. Rinsho Ketsueki. 1987;28(7):1165-9.
  23. Hupperets P, De witte T, Haanen C. A retrospective study of the effect of anabolic steroids on the dyshaematopoietic syndrome (preleukaemic syndrome). Neth J Med. 1983;26(7):181-7.
  24. Komatsu S. [CLINICAL USE OF PROTEIN ANABOLIC STEROID “PRIMOBOLAN” FOR UROLOGICAL DISEASES]. Hinyokika Kiyo. 1964;10:220-5.
  25. Essers U. [Effects of testosterone and methenolone on erythropoietin activity and erythropoiesis in patients with kidney failure]. Med Welt. 1971;48(71):1918-9.
  26. Kmieć Z, Kugler P. [Electron microscopic-morphometric and biochemical studies of the kidney of male rats following castration and treatment with an anabolic steroid]. Z Mikrosk Anat Forsch. 1984;98(2):267-76.
  27. Schwarzlose W, Truckenbrodt H, Heim F. [The influence of 1-methyl-delta1-androsten-17-ol-3-one 17-enanthate on the size as well as DNA-, RNA-, and protein content of individual kidney cells as a function of the age of the animals]. Med Pharmacol Exp Int J Exp Med. 1967;17(3):224-30.
  28. Lagrot F, Costagliola M, Micheau P, Mansat C. [BURN PATIENTS OVER LONG PERIODS AND THEIR TREATMENT. THE PLACE OF ANABOLIC STEROIDS (METHENOLONE ENANTHATE)]. Bull Mem Soc Chir Paris. 1965;55:129-38.
  29. Frankle M, Borrelli J. The effects of testosterone propionate and methenolone enanthate on the healing of humeral osteotomies in the Wistar rat. J Invest Surg. 1990;3(2):93-113.
  30. Hussain Z, Dastagir N, Hussain S, et al. Aspergillus niger-mediated biotransformation of methenolone enanthate, and immunomodulatory activity of its transformed products. Steroids. 2016;112:68-73.
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