MK-677, also known as ibutamoren or ibutamoren mesylate, belongs to a group called growth hormone secretagogues. They are substances that boost the production of growth hormone (GH). MK-677 can also increase the production of insulin-like growth factor 1 (IGF-1), a hormone similar in molecular structure and function to insulin. The ability of MK-677 to boost the levels of GH and IGF-1 is associated with a wide array of health benefits.
The exact mechanism by which MK-677 exerts these effects is by mimicking the action of ghrelin (hunger hormone) and binding to one of the growth hormone secretagogue receptors (GHSR) in the brain.  This in turn boosts growth hormone (GH) levels. Interestingly, GHSR is located in certain regions of the brain that regulate appetite, mood, pleasure, and cognitive function.  Because of this, researchers believe that MK-677 can have beneficial effects on these functions. In addition, MK-677 is also classified as a selective androgen receptor modulator (SARM), a class of therapeutic compounds similar in function to anabolic agents, but with lesser side effects. This makes MK-677 a safe and effective form of GH and IGF-1 replacement therapy.
MK-677 is frequently used as an anabolic substance, which means that it has the ability to increase muscle mass and strength while promoting fat loss. Studies show that this powerful compound can help improve body composition and prevent muscle wasting related to old age and other medical conditions:
Aside from improving body composition, MK-677 also has the ability to maintain healthy bones and prevent various bone disorders such as osteoporosis and fractures. There is strong scientific evidence supporting the beneficial effects of MK-677 on overall bone health:
The aging population is highly at risk for sleep problems and disorders that can significantly affect the quality of life. Whether it is age-related or caused by a certain medical condition, MK-677 supplementation may help improve sleep quality and quantity according to numerous clinical research:
Doctors usually prescribe MK-677 for patients suffering from cognitive impairment because of its nootropic effects. Nootropics are drugs, supplements, and other substances that have the ability to improve certain aspects of cognitive function such as learning, memory, creativity, and motivation. Several high-quality studies support the many beneficial effects of MK-677 as a cognitive enhancer:
Growth hormone secretagogues such as MK-677 have the ability to accelerate the repair of damaged tissues caused by physical trauma or sports-related injuries. There is compelling evidence supporting the regenerative properties of MK-677:
Heart disease ranks among the top in terms of mortality worldwide. Interestingly, MK-677 possesses potent cardioprotective properties that can help reduce the prevalence of heart disease and the rate of deaths associated with this condition. Recent research shows that MK-677 and other growth hormone secretagogues can help preserve heart function through various important mechanisms:
MK-677 and other growth hormone secretagogues have the ability to enhance the immune response. Studies show that they play a role in the regulation of immune function through the following important mechanisms:
The ability of MK-677 to positively influence the levels of vital hormones such as GH and IGF-1 can help improve sex drive and sexual function. There is strong scientific evidence supporting the beneficial effects of MK-677 and other growth hormone secretagogues on the sexual health of both men and women:
MK-677 and other growth hormone secretagogues have potent anti-diabetic properties. There is compelling evidence supporting the ability of MK-677 to bring down elevated levels of blood sugar in diabetic patients and animal models:
Chronic elevation in cholesterol levels significantly increases one’s risk of stroke, heart disease, hypertension, and other deadly diseases. According to studies, one can greatly reduce their risk for these debilitating medical conditions by reducing cholesterol levels through MK-677 supplementation:
MK-677 side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on MK-677. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of MK-677. Despite this, it was listed as a side effect associated with MK-677 even though these associated side effects are very uncommon.
Side effects associated with MK-677 may include the following:
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