Tesamorelin is an FDA-approved drug for lipodystrophy, a medical condition characterized by an abnormal distribution of body fat. This small molecule (known as peptides) is a synthetic analog of growth hormone–releasing factor, which means that it stimulates the pituitary gland to secrete growth hormone (GH). This mechanism is thought to play an integral role in body fat reduction since direct GH administration has fat-burning effects.
Tesamorelin stimulates the synthesis and release of GH by acting on the pituitary cells in the brain. The increase in GH also increases the levels of insulin-like growth factor (IGF-1). This in turn stimulates muscle growth and fat loss.
Fat reduction is the major benefit of tesamorelin. In fact, the US Food and Drug Administration approved tesamorelin last November 2010 for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Several lines of evidence clearly support this fat-burning effect:
Growth hormone–releasing hormone (GHRH) such as tesamorelin has potent effect on brain function. Studies show that this “cognitive enhancer” may benefit people with age-related memory problems and those suffering from chronic, progressive mental deterioration:
The ability of tesamorelin to improve lipid profile can be attributed to its fat-burning effect and GH-boosting properties. High-quality studies support its beneficial effect on triglycerides, total cholesterol, low-density lipoprotein (bad cholesterol), and high-density lipoprotein (good cholesterol):
Studies also show that tesamorelin may benefit liver function through various important mechanisms:
Clinical trials also show that tesamorelin can bring down high blood sugar levels by promoting fat loss:
Evidence suggests that tesamorelin can help reduce the risk of cardiovascular diseases by improving various health parameters such as triglyceride levels and total cholesterol levels.  Tesamorelin also has the ability to raise the levels of high-density lipoprotein (good cholesterol).  An increase in HDL cholesterol is associated with significant cardiovascular disease risk reduction. 
Nerve injury is one of the most debilitating medical conditions and perhaps one of the most difficult to treat as it can lead to permanent impairment in motor and sensory function of the affected area. Research, however, suggests that growth hormone-based therapies such as tesamorelin treatment can speed up the rate of healing of damaged nerves. 
Tesamorelin side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on tesamorelin. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of tesamorelin. Despite this, it was listed as a side effect associated with tesamorelin even though these associated side effects are very uncommon.
Side effects associated with tesamorelin may include the following:
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