Pregnenolone is a steroid hormone produced primarily in the adrenal glands. Smaller amounts of pregnenolone are also produced in other organs such as the brain, skin, gonads, liver, and eyes. In the body, all hormones work in harmony to create a healthy balance. If you picture steroid hormones as a cascade, where one hormone has an impact on one another, pregnenolone would be at the top of the cascade.
Pregnenolone is manufactured directly from cholesterol – which is one reason why experts believe that below the normal levels of cholesterol can cause hormonal imbalance. In turn, several other hormones including testosterone, DHEA, estrogen, and cortisol are synthesized from pregnenolone that’s why it is called as the “mother of all steroid hormones”. Just as it’s used to synthesize other steroid hormones, adequate amounts of pregnenolone are used to create neurohormones in the brain, which act to maintain healthy nerve cell function and regulate mood.
Pregnenolone has several important functions in the body aside from acting as the main precursor for most steroid hormones. It seems to have a balancing effect to many other hormones by increasing or decreasing their levels when necessary. In addition, pregnenolone also regulates the transmission of messages between each nerve cell (neuron) to strongly influence many other processes in the brain and other body systems.
As we age, the levels of pregnenolone fall dramatically to as much as 60 percent. Researchers have linked this hormonal imbalance to a wide array of debilitating medical conditions that can affect overall quality of life. Unpleasant symptoms related to low pregnenolone include:
Several Bioidentical hormone replacement programs tend to use pregnenolone because it is touted as the “mother of all steroid hormones”, thus, it can boost overall health by bringing the levels of other vital hormones up as needed. In fact, pregnenolone is effectively used in conjunction with testosterone and estrogen to help relieve various symptoms of menopause and andropause (male menopause). With pregnenolone supplementation, the goal is to support overall healthy levels of this hormone in order to stimulate the body to produce internal pregnenolone in areas that need a boost of another steroid hormone. This powerful hormone is available in the form of injections, tablets, and topical creams. Strong scientific evidence suggests that different modes of prenenolone administration are highly safe and effective in treating various medical conditions and improving overall health:
Pregnenolone is a nootropic agent or “cognitive enhancer”. This means that it has the ability to improve various aspects of cognitive function including memory, learning, and thinking skills. Studies show that pregnenolone boosts cognitive function through several important mechanisms:
In both men and women, pregnenolone deficiency can dramatically affect sleeping pattern and quality. As a pro-hormone responsible for the production of several vital sex hormones, pregnenolone in its healthy levels can stimulate deep sleep. Research into sleep is showing a strong connection between pregnenolone and its ability to promote normal sleep pattern:
Schizophrenia is a long-term mental health condition that causes a wide array of psychological symptoms such as hallucinations, delusions, muddled thoughts, and changes in behavior. Currently, treatment for schizophrenia includes antipsychotic medicines and cognitive behavioral therapy (talking therapy). There is increasing evidence that pregnenolone administration can be considered as a therapeutic option for this debilitating mental condition:
Decreased levels of pregnenolone are strongly linked with depressed mood. [83-84] Because depression can be very challenging to treat, with current medications requiring months before its therapeutic effects are achieved, research into pregnenolone on mood can be a game-changer. Interestingly, clinical studies assessing the beneficial effects of pregnenolone on mood, depression, anxiety, and other mental disorders show positive results:
With advancing age, the immune system weakens making us susceptible to various infections. Interestingly, pregnenolone does have immune-modulating properties that can help boost the immune response, thereby warding off a wide array of diseases. Strong scientific evidence supports the beneficial effects of pregnenolone on the immune system:
Chronic alcohol intake significantly increases the risk of liver disease and other fatal medical conditions. Studies show that pregnenolone administration may offer long-term solution to chronic alcoholism:
In addition to its already potent neuroprotective properties, pregnenolone might also be able to combat certain types of cancer. There is strong scientific evidence that supports the cancer-fighting properties of pregnenolone:
Marijuana, also known as cannabis, is the most commonly used illegal drug in the world. While some states or countries permit its use, chronic marijuana administration can lead to serious side effects such as panic attack, intense anxious or fearful feelings and thoughts, and acute psychosis. With its neuroprotective properties, studies show that pregnenolone may help protect against the negative effects cannabis intoxication:
The logic behind the cholesterol-lowering effect of pregnenolone is simple – it is manufactured directly from cholesterol. To put it simply, when pregnenolone levels increase, cholesterol levels decrease. Studies on pregnenolone support its cholesterol-lowering effects:
Sexual desire and function declines with advancing age. This is because the levels of many other hormones that regulate sex drive (testosterone and estrogen) also decline gradually. As the “mother of all hormones”, studies show that pregnenolone can help restore youthful levels of other hormones, thereby ramping up sexual power:
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