Obesity may significantly impact one’s quality of life, as it can negatively affect independent movement and exercise. While this condition can cause physical and emotional problems, it can also increase one’s risk for deadly diseases such as heart problems, diabetes, cancer, stroke, and non-alcoholic liver failure. Unfortunately, once you become obese, this condition is extremely difficult to reverse or even treat effectively. This is because obesity affects the body’s ability to break down fat stores and use it as a source of energy. In fact, even drugs that have been designed to boost fat breakdown may be ineffective. Therefore, body fat accumulates over time and becomes very challenging to remove without surgical intervention.
Recently, a new breakthrough may help patients with this severe form of obesity achieve healthier weight. The NNMT inhibitor 5-amino-1-methylquinoline or 5-amino-1MQ has been shown to reduce the production of the enzyme nicotinamide N-methyltransferase (NNMT), a regulator of energy homeostasis in adipose tissue (a type of fat used for energy storage). This mechanism could shrink white adipose tissue and dramatically reduce weight without the need for limiting calorie intake.
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