Combats Various Cancer Types

A number of high quality studies also suggest that high levels of NNMT are strongly linked with the development of various types of cancer, suggesting a potential therapeutic role for NNMT inhibitors:
1. NNMT levels are significantly increased in primary glioblastoma tumors (aggressive brain tumors) compared to normal human brain samples. [15]
2. Enhanced NNMT production is also increased in human papillary thyroid cancer cell lines. [16]
3. In renal clear cell carcinoma, NNMT production is also significantly increased. [17]
4. In human bladder cancer, NNMT was found to be a major regulator of cell migration. [18]
5. The NNMT protein is also increased in gastric cancers. [19-20]
6. NNMT is also identified as a novel serum tumor marker for human colorectal cancers and oral squamous cell carcinoma. [21-22]
7. NNMT knockdown (NNMT gene loss) decreased proliferation and migration of bladder cancer cells. [23]
8. NNMT knockdown also inhibited the proliferation and/or metastasis of kidney cancer cells, pancreatic cancer cells, and oral squamous carcinoma. [24-26]
9. In non-small-cell lung cancer cells, inhibition of NNMT production resulted in suppression of tumor growth. [27]
10. Higher levels of NNMT in tumor tissues are associated with lower overall survival rates in cancer patients, suggesting that NNMT inhibitor administration may help improve survival. [28]
11. In human oral cancer cell line, administration of NNMT inhibitor dramatically reduced cancer cell growth and reproduction. [29]

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