Evidence suggests that the enzyme NNMT is highly associated with inflammatory conditions and related injuries, suggesting that NNMT inhibitors like 5-amino-1MQ may have an anti-inflammatory role:
1. Significantly increased levels of NNMT have been observed in the lungs and skeletal muscle of patients with chronic obstructive pulmonary disease (COPD) with muscle wasting. [9-10]
2. Increased NNMT levels were also seen in the skeletal muscle of patients with various forms of muscular abnormalities. 
3. Experimental studies in mice also found an increase in NNMT levels after drug-induced liver injury. [12-13]
4. A study found that NNMT production is the body’s protective compensatory response to injury, resulting in inflammatory states. 
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