As a NNMT inhibitor, 5-amino-1MQ’s weight-reducing effects could produce additional benefits such as improvement of cholesterol profile and reduction of blood sugar levels.
A 2018 study published in the Dibetes Journals investigated the effects of NNMT inhibitor in diet-induced obese (DIO) mice maintained on a high-fat diet.  During the study period, the researchers assessed different health parameters such as fat mass, oral glucose tolerance, fat cell levels, and circulating lipids.
Interestingly, results showed that systemic treatment of DIO mice with a potent NNMT inhibitor dramatically reduced body weight, fat mass, fat cell size, blood sugar levels, and plasma cholesterol levels. In addition, researchers observed that the treatment did not alter food intake nor produce any adverse side effects. These results suggest that NNMT inhibitors can help improve body composition as well as cholesterol and blood sugar levels.
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