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Aminophylline administration can also help treat sleeping difficulties associated with various medical conditions:
1. In healthy male volunteers, aminophylline administration normalized high-altitude sleep-disordered breathing. [48]
2. In patients with obstructive sleep apnea syndrome, aminophylline improved impaired breathing and increased NREM (non-rapid eye movement) sleep or dreamless sleep. [49]
3. In patients with sleeping difficulties related to acute mountain sickness, aminophylline administration improved sleep efficiency without any adverse effects. [50]

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