Treats Lung Diseases/Injuries

Aminophylline is often prescribed for a multitude of lung conditions. There’s robust evidence supporting the benefits of this drug on pulmonary health:
1. In adults hospitalized for acute asthma, treatment with aminophylline was associated with fewer nebulizations of albuterol and lower rate of exacerbations. [1-2]
2. In patients with acute severe asthma, aminophylline infusions improved lung function and symptoms. [3]
3. In patients with respiratory fatigue, aminophylline administration reduced the risk of intubation. [4]
4. In patients with partially reversible severe airway obstruction, intravenous injections of aminophylline (250 mg) was associated with consistent improvement in the mean forced expiratory volume, a measure of how much air a person can exhale during a forced breath. [5]
5. In patients with acute exacerbation of asthma or chronic obstructive pulmonary disease, aminophylline infusion decreased hospital admissions. [6]
6. In patients with chronic obstructive pulmonary disease (COPD), aminophylline administration improved symptoms by reducing the levels of inflammatory markers. [7]
7. In patients with COPD, oral administration of aminophylline (400 mg) increased mean forced expiratory volume and forced vital capacity. [8-9]
8. In patients with COPD, low dose aminophylline increased the efficacy of inhaled corticosteroids by reducing the incidence of exacerbations. [10-11]
9. In patients undergoing valve replacement, aminophylline administration had anti-inflammatory effect and improved pulmonary oxygenation. [12]
10. Prolonged use of maintenance aminophylline therapy in COPD patients increased diaphragmatic contractility and endurance and improved several aspects of mucociliary function (defense mechanism of the lung). [13]
11. Administration of long-acting 225-mg aminophylline compounds twice daily for 8 weeks improved peak expiratory flow rate in younger COPD patients and relieved symptoms of chest tightness in older COPD patients. [14]
12. Aminophylline administration in COPD patients enhanced the anti-inflammatory effect of corticosteroids. [15]
13. In patients with chronic bronchitis and moderate to severe chronic obstruction to airflow, aminophylline administration at 800 mg daily led to an improvement in peripheral ventilation. [16]
14. In normal young adults, aminophylline prevented alterations in breathing pattern. [17]
15. In patients with mild asthma, low-dose aminophylline led to a significant reduction in mean sputum eosinophils (a measure of allergic reaction). [18]
16. In patients with atopic asthma, aminophylline administration at 200 mg every 12 hours reduced airway inflammatory response to allergen inhalation. [19]

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