Cognitive Health

An overwhelming body of high quality studies supports the therapeutic benefits of aniracetam on the brain. According to these studies, aniracetam exerts its brain-boosting effects through the following important mechanisms:
1. In rats, aniracetam increases the release of the neurotransmitter (brain chemical) acetylcholine, which is critical for various brain functions such as learning and memory. [1-4]
2. In rats, aniracetam also increases the levels of the neurotransmitters dopamine (plays a major role in reward-motivated behavior) and serotonin (affects memory). [5-7]
3. In rats, aniracetam enhances the transmission of electrical signals in the hippocampus, a small region of the brain involved in learning and memory. [8]
4. In elderly patients with mild to moderate cognitive impairment due to senile dementia of the Alzheimer type, aniracetam administration at a dose of 1500 mg/day appears to alleviate memory damage and learning impairments caused by various traumas at 4 and 6 months of treatment. [9]
5. In patients with cognitive impairment, aniracetam prevents further cognitive decline at 6 months of treatment. [10]
6. Aniracetam modulates the activity of the AMPA receptor, which mediates fast transmission of electrical signals in the central nervous system. [11-13]
7. Aniracetam boosts the levels of the neurotransmitter noradrenaline or also known as norepinephrine, which enhances cognitive function during stressful situations. [14]
8. In rats, aniracetam enhances the transmission of gamma-aminobutyric acid (GABA), which is necessary to fine-tune communication between nerve cells (neurons). [15]
9. In rats, aniracetam can potentially reverse neurological changes or alleviate symptoms associated with Alzheimer’s disease and Parkinson’s disease. [16-17]
10. In rats, aniracetam administration at a dose of 50 mg/kg bodyweight appears to alleviate some cognitive deficits in the hippocampus caused by Fetal Alcohol Syndrome (FAS). [18]
11. In rats, oral aniracetam administration at doses of 10-100 mg/kg appears to normalize or improve cognitive impairment. [19]
12. In aged rats and middle-aged mice, aniracetam increases the levels of brain-derived neurotrophic factor (BDNF), a protein that promotes the survival of nerve cells in the brain. [20]

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