Studies show that BPC-157 effectively reduces the adverse side effects and toxicity of NSAIDs through the following protective mechanisms:
1. In rats, BPC-157 effectively counteracts several established side-effects of NSAIDs use such as lesions in the gastrointestinal tract, liver and brain, prolonged bleeding, and low blood platelet count (thrombocytopenia). 
2. In rats, oral supplementation and injection of BPC-157 effectively treats severe gastric, intestinal and liver lesions, liver problems, prolonged sedation/unconsciousness, brain abnormalities, and organ failure induced by NSAIDs. [25-28]
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