Wards Off Depression

Evidence suggests that cabergoline has antidepressant effect. Studies show that this may be attributed to its ability to mimic dopamine activity and reduce prolactin levels:
1. In patients with depression who failed to attain complete remission, cabergoline treatment resulted in dramatic improvement in energy levels and fatigue. [21]
2. In patients with major depressive disorder induced by hyperprolactinemia, cabergoline treatment led to complete absence of depressive symptoms. [22]
3. Addition of cabergoline in the treatment regimen of patients with depression augmented the effect of antidepressants. [23]
4. In rats, cabergoline administration produced anti-depressant effect as evidenced by decreased immobility time in the forced swimming test. [24]