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Prolonged use of morphine changes the way nerve receptors in the brain work. As a result, sudden withdrawal from this drug can lead to debilitating symptoms such as sleep problems, restlessness, anxiety, digestive problems, high blood pressure, rapid heartbeat, and vision problems. Studies show that morphine withdrawal activates heat shock protein which is believed to trigger these unpleasant symptoms. [40] Interestingly, rat studies show that cerebrolysin counteracts the activation of heat shock protein, suggesting that it may help fight the negative effects of morphine withdrawal. [41]
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