Contrave is an FDA-approved drug for adults with a body mass index (BMI) of 30 or higher who wants to lose weight. In some cases, doctors recommend this drug for patients with a BMI of 27 or higher who have one or more weight-related condition or illness, such as hypertension, high cholesterol, or type 2 diabetes.  The active ingredients in contrave are bupropion, an antidepressant, and naltrexone, a drug used to combat opioid addiction.
The exact neurochemical mechanism by which contrave exerts its weight loss effects is by affecting the function of the hypothalamus, the hunger center of your brain. This in turn promotes satiety, reduces food intake, and boosts energy expenditure. The combination of bupropion and naltrexone also work on the mesolimbic pathway, the brain network that provides rewarding feelings. By regulating this pathway, food-seeking behaviors will be significantly reduced.
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