Promotes Weight Loss

The main benefit of this FDA-approved drug is to help overweight and obese people achieve healthier weight and lower their risk for weight-related medical conditions. An overwhelming body of clinical evidence supports this:
1. In overweight/obese individuals with type 2 diabetes, administration of 32 mg naltrexone sustained-release (SR)/360 mg bupropion SR (NB) resulted in significantly greater weight reduction. [2]
2. In non-diabetic patients, three phase 3 trials of naltrexone SR plus bupropion SR (NB) demonstrated significant weight loss without any adverse side effects. [3-5]
3. When combined with lifestyle intervention and modest calorie reduction, the naltrexone–bupropion combination appears to achieve clinically significant weight loss (over 5% of total body weight) after 6 months to 1 year of treatment. [6]
4. A study found that contrave treatment was associated with 3 to 7% weight loss and improvements in obesity-related comorbidities and cardiovascular risk factors. [7]
5. Patients who received 1 year of naltrexone ER/bupropion ER combination therapy with greater than 5% weight lost are likely to maintain clinically significant results. [8]
6. In overweight and obese patients, naltrexone/bupropion (NB) combination therapy was associated with significantly greater weight loss. [9]
7. In patients with uncomplicated obesity, combined bupropion and naltrexone therapy caused gradual sustained weight loss over 48 weeks. [10]
8. In middle-aged white females, contrave treatment significantly reduced weight. [11-13]
9. In obese mice, contrave significantly reduced weight by increasing the activity of POMC cells, which are peptides that play an integral role in weight regulation. [14]
10. Direct injection of bupropion and naltrexone in mice produced greater reduction in food intake. [15-16]
11. In obese patients, contrave treatment reduced body fat and visceral adipose tissue. [17]
12. A study found that contrave has a greater weight loss efficacy than other FDA-approved drugs for obesity, such as orlistat and lorcaserin. [18]
13. A study also found that contrave has favorable effects on obesity or medication-related weight gain. [19]

before after

At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

- Nick Cassavetes, 60 yrs old

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