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DHEA and Inflammation

Inflammation is the root cause of most diseases and is strongly linked with almost all age-related health problems. DHEA’s potent anti-inflammatory properties can help ward off various inflammatory disorders associated with advancing age and improve overall quality of life. Several research studies confirm the anti-inflammatory effects of DHEA:
1. DHEA protects human neurons (nerve cells) from HIV-associated inflammation and prevents degeneration. [154-155]
2. In patients with chronic inflammatory diseases, DHEA replacement therapy reduces the levels of inflammatory markers. [156]
3. In patients with asthma and allergies, DHEA attenuates T helper 2 allergic inflammation and reduces airway hyperreactivity. [157]
4. In patients with inflammatory bowel disease, DHEA restrains intestinal inflammation by modifying white blood cell activity and balancing the exacerbated immune responses. [158]
5. In patients with Crohn’s disease and ulcerative colitis, DHEA decreases disease activity without any adverse side effects. [159]
6. In patients with systemic lupus erythematosus (SLE), a chronic inflammatory disease, DHEA administration reduces dose of prednisone (thus avoiding its adverse effects) while also improving symptoms. [160]
7. DHEA stops inflammation and restores normal colon length in mouse models of inflammatory bowel disease. [161]
8. In mice, DHEA administration decreases the systemic inflammatory response induced by bilateral femoral fracture. [162]
9. In animal models, DHEA suppresses experimental brain inflammation by reducing the levels of inflammatory substances. [163-168]

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