DHEA and Blood Sugar

Acquiring more DHEA can help combat diabetes and other diseases linked with high blood sugar levels. Results of human studies assessing the anti-diabetic effects of DHEA suggest that it can protect against insulin resistance induced by aging and unhealthy lifestyle:
1. In older men and women, 6 months of DHEA replacement therapy improves insulin action, thereby reducing blood sugar levels. [241]
2. In women with stress hormone deficiency, DHEA replacement therapy lowers blood sugar levels by improving the body’s response to insulin. [242]
3. In older men and women, DHEA treatment at a dose of 50 mg daily for 6 months reduces adiposity while improving blood sugar levels. [243]
4. In middle-aged and elderly men and women, higher DHEA levels are associated with a lower risk of type 2 diabetes. [244]
5. In older men and women, DHEA prevents insulin resistance by reducing the levels of inflammatory cytokines such as IL-6 and TNFα. [245-250]
6. DHEA reverses insulin resistance by activating peroxisome proliferator-activated receptor (PPARα), a group of proteins that play a role in the metabolism of carbohydrates, lipids, and proteins. [251-261]
7. Another mechanism by which DHEA improves insulin action is by improving the activation of phosphatidyl inositol 3-kinase and Akt/PkB pathway, both of which play a key role in blood sugar metabolism. [262-264]

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