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DHEA and Bone Health

DHEA possesses potent anti-aging properties that help protect against loss of bone mineral density and strength, thereby reducing the risk of fractures and osteoporosis. Apart from aging, bone loss occur at higher rates in people with hormonal imbalances, poor eating habits, unhealthy lifestyle, and those with medical conditions that affect bone quality. As the “mother of all hormones”, evidence suggests that DHEA replacement therapy improves bone production and quality by boosting the production of other hormones necessary for bone production:
1. In elderly men and women, DHEA replacement therapy significantly increases bone mineral density and the levels of the bone-boosting hormones insulin-like growth factor 1 and testosterone. [169-172]
2. In women, 12 months of DHEA treatment increases bone mineral density of the lumbar spine as well as estrogen levels. [173-174]
3. In men and women with low levels of DHEA due to disease, short duration of DHEA treatment improves bone mineral density and bone metabolism. [175-180]
4. In older healthy individuals, DHEA prevents bone loss and osteoporosis. [181-182]
5. DHEA acts protectively against osteoporosis by increasing bone-forming cells known as osteoblasts. [183]
6. In older women, DHEA supplementation improves bone mineral density when co-administered with vitamin D and calcium. [184]
7. In older adults, long-term (12–24 months) DHEA replacement therapy significantly increases or preserves bone mineral density while preventing bone breakdown. [185-188]
8. In young adults, DHEA decreases bone breakdown and increases bone formation without any adverse side effects. [189]
9. In young women with anorexia nervosa (eating disorder characterized by fear of gaining weight and strong desire to be thin), DHEA treatment significantly increases bone mineral density of both hip and spine. [190]
10. In postmenopausal women, higher DHEA levels are associated with lesser bone loss. [191]
11. In postmenopausal women, DHEA treatment significantly increases bone mineral density as well as blood levels of osteocalcin, a marker of bone formation. [192]

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At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

- Nick Cassavetes, 60 yrs old

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