DHEA and Pregnancy Rate

For women who want to increase their chances of getting pregnant, DHEA supplementation can help. In fact, DHEA supplements are actually prescribed by doctors in women with diminished ovarian reserve (DOR), a condition in which the ovaries lose their reproductive potential. Several clinical trials assessing the beneficial effects of DHEA replacement therapy on pregnancy rate have shown positive outcomes for many women:
1. In young women who do not respond well to in vitro fertilization (IVF), DHEA supplementation at dose of 25 mg three times daily for at least 12 weeks significantly increases spontaneous pregnancy rate. [223]
2. In women with lower fertility rates, DHEA improves ovarian function, increases pregnancy chances and lowers miscarriage rates. [224]
3. DHEA significantly reduces miscarriages in women by preventing aneuploidy (presence of an abnormal number of chromosomes in a cell). [225-229]
4. In women with lower fertility rates, DHEA supplementation improves pregnancy rate by increasing the number and quality of oocyte (egg cell) and embryo. [230-232]
5. In women with hormonal imbalances, DHEA supplementation for at least 3 months is associated with spontaneous and treatment-induced pregnancies. [233-234]
6. In women with DOR, DHEA replacement therapy increases the levels of Anti-Mullerian Hormone (AMH), an indicator of good ovarian reserve. [235]

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