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DHEA and Skin Health

DHEA can reduce wrinkles and other skin imperfections associated with aging. Studies show that this hormone exerts its anti-aging effect through various mechanisms:
1. In postmenopausal women aged 60-65 years, skin application of DHEA cream twice daily for 13 weeks improves skin health and appearance by increasing the levels of collagen, a protein that makes the skin radiant and younger-looking. [367]
2. In postmenopausal women, skin application of DHEA cream is associated with greater procollagen and collagen production. [368-370]
3. In older women, oral DHEA supplementation at a dose of 50 mg daily for 1 year improves skin hydration, skin thickness and oil production, and reduces skin pigmentation. [371]
4. In patients with skin atrophy (skin thinning), oral DHEA prevents frequent skin tearing. [372]
5. In postmenopausal women, skin application of DHEA cream reduces wrinkles and blemishes. [373]
6. In postmenopausal women, DHEA decreases the production of the collagenase enzymes that destroy collagen. [374]
7. DHEA also decreases the production of genes associated with the formation of calluses and rough skin in postmenopausal women. [375]

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