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Estrogen and Immune Function

With aging, estrogen levels along with immune function start to decline predisposing a person to wide array of diseases. This is because sex hormones such as estrogen are known as the “master regulators” of the immune system. Therefore, restoring estrogen to youthful levels through ERT can significantly boost immune function and prevent fatal illnesses related with advancing age. An increasing number of scientific evidence supports the “immune-boosting” effect of estrogen:
1. In patients with early breast cancer, ERT does not increase either the risk of recurrence or of death. [491]
2. In patients with rheumatoid arthritis and systemic lupus erythematosus, ERT is associated with decreased risk of disease flare and improvement in disease activity. [492]
3. In perimenopausal women, ERT regulates immune function by increasing immune cells such as CD8+ cells. [493]
4. In postmenopausal women, ERT reverses immune alterations associated with normal aging. [494]
5. In postmenopausal women, ERT restores immune balance by enhancing antibody-mediated immunity. [495]
6. The use of ERT alone in female patients is associated with a significant reduction in lung cancer risk and related death. [496-499]
7. Estradiol reduces programmed cell death (apoptosis) of immature B cells of the immune system. [500]
8. Estrogen indirectly boosts the immune function by modulating the levels of growth hormone, prolactin, or thymosin. [501]
9. In postmenopausal women with arthritis, ERT significantly decreases disease activity and signs of inflammation. [502]
10. In postmenopausal women, ERT reverses the deleterious effects of aging on the immune system by increasing the number of B-cells and improving T-cell function. [503]
11. In postmenopausal women, ERT improves immune function by reducing elevated blood levels of the pro-inflammatory cytokines TNF-α, IFN-γ and IL-6. [504-507]

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At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

- Nick Cassavetes, 60 yrs old

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