A good deal of evidence also suggests that aminophylline can improve body composition by reducing body fat percentage and promoting lean muscle mass:
1. In overweight men and women, application of 0.5% aminophylline cream to the waist twice a day was associated with significant reduction in waist circumference. 
2. In participants with fat deposits on their thighs, application of aminophylline lotion significantly reduced thigh circumference, thigh skinfold thickness, and thigh fat mass. 
3. Twelve weeks of 0.5% aminophylline cream administration significantly decreased waist-to-hip ratios in overweight female participants compared to male participants. 
4. A study found that aminophylline promotes fat loss by inducing breakdown of fat cells. 
5. In women with lower body fat distribution, application of aminophylline cream significantly reduced thigh fat. 
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