Combats Inflammatory Conditions

Numerous studies suggest that the potent anti-inflammatory properties of glycyrrhetinic acid allow it to treat a multitude of inflammatory conditions:
1. A study found that glycyrrhetinic acid contains substances that are very effective in suppressing inflammatory markers such as nuclear factor-κB (NF-κB) and 12-O-tetradecanoylphorbol-13-acetate. [64]
2. In healthy volunteers and in patients with chronic moderate/severe blepharitis (eyelid inflammation), administration of glycyrrhetinic acid ophthalmic solution showed good clinical anti-inflammatory activity. [65]
3. In mice with arthritis, glycyrrhetinic acid treatment reduced symptoms. [66]
4. In mice with heart muscle inflammation (myocarditis), glycyrrhetinic acid treatment reduced the degree of swelling. [67]
5. In contact hypersensitivity model mice, glycyrrhetinic acid administration resulted in an anti-allergic effect as evidenced by reduced skin inflammation. [68]
6. In mice with spinal cord compression injury, glycyrrhetinic acid administration reduced secondary inflammatory process. [69-70]
7. In mice with allergic rhinitis, glycyrrhetinic acid treatment was associated with enhanced antioxidant status and improved immunity activities in the blood and nasal mucosa. [71]
8. In mice with nerve inflammation, glycyrrhetinic acid treatment inhibited pro-inflammatory mediators in the brain tissue. [72]
9. Glycyrrhetinic acid treatment also alleviated asthmatic features in mice. [73-74]
10. In rats, glycyrrhetinic acid treatment ameliorated intestinal inflammation. [75]