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There is also increasing evidence that supports the anti-diabetic effect of glycyrrhetinic acid:
1. In mice, supplementation of an extract containing glycyrrhetinic acid improved glucose tolerance. [8]
2. In streptozotocin-diabetic rats, administration of 18beta-glycyrrhetinic acid was able to reduce hyperglycemia (high blood sugar levels). [9]
3. In adult male rats, 18beta-glycyrrhetinic acid administration was associated with increased antioxidants status and decreased lipid peroxidation, which reflects protective effect against diabetes risk. [10]
4. A cell study found that glycyrrhetinic acid has protective effects against high blood sugar levels and oxidative stress. [11]
5. In noninsulin-dependent diabetes mouse model, glycyrrhetinic acid supplementation improved tolerance to oral glucose loading 9 weeks after the beginning of test feeding. [12]
6. In rats with streptozotocin-induced diabetes, glycyrrhetinic acid treated hyperglycemia, hyperlipidemia and associated oxidative stress, suggesting that it may be a potential therapeutic agent for diabetes treatment. [13]

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