Numerous studies have shown that lower GH levels are strongly linked with a higher risk of cardiovascular disease and related deaths. [345-354] The degree of GHD is directly related to elevated levels of total cholesterol and low-density lipoprotein (bad cholesterol), increased truncal fat, abnormal waist–hip ratio, and risk of hypertension – all of these factors can increase one’s risk for death related to heart diseases.  Interestingly, a meta-analysis of clinical studies assessing various cardiovascular parameters were investigated in patients treated with GH and the results of the study showed significant improvements in lean body mass, total cholesterol, LDL cholesterol, and diastolic blood pressure. [356-358] Similarly, a study by Agarwal et al. has shown that treatment of GH deficiency through GH replacement therapy may help improve outcomes in heart failure.  In another study, Tritos et al. reported that patients with congestive heart failure (CHF) who received recombinant human growth hormone (rhGH) therapy had improved exercise duration and increased cardiac output.  Finally, in a meta-analysis of several clinical trials assessing the therapeutic benefits of GH therapy on cardiac function, Volterrani et al. reported that patients with CHF who received the treatment experienced a significant improvement in their symptoms without any adverse side effects. 
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