GH and Cognitive Health

Patients with Growth Hormone Deficiency (GHD) often suffer from low energy levels, mood changes, mental fatigue, and cognitive impairment. [324-328] Interestingly, a study by Wallymahmed et al. have shown that GH replacement therapy in GHD patients for 6 to 12 months led to significant improvements in body composition, muscle strength, energy levels, emotional reactions, and self-esteem scores. [329] In another study, Sathiavageeswaran et al. demonstrated that up to 70% of patients with the fibromyalgia syndrome (long-term condition that causes pain all over the body) who received GH replacement therapy had significant improvements in perceived energy levels, body image, pain level and cognition. [330] Other studies have also shown that GH replacement therapy in GH-deficient individuals resulted in significant improvements in various parameters of cognitive health such as memory, language function, attentional performance, thinking skills, and quality of life. [331-341] Numerous studies even found that GH replacement therapy in patients with traumatic brain injury induced reduction of depression, social dysfunction, and certain cognitive domains. [342-344]