GH and Muscle Health

There is a significant association between reduced lean muscle mass and impaired neuromuscular function. [376] In one study, a significant improvement in lean mass and neuromuscular function was observed after more than 10 years of GH replacement therapy. [377] In a very interesting study of patients with the fibromyalgia syndrome, 70% of patients with GHD showed a marked improvement in symptoms following GH replacement therapy. [378] In states of GH deficiency, Weber et al. reported that reduced muscle mass and strength can be reversed successfully with supplementation of GH. [379] In men over 50 years old, GH supplementation is associated with a statistically significant increase in muscle strength in the lower body part, suggesting that GH may help prevent the age-related decline in muscle function. [380-381] In patients with adult-onset and childhood-onset adult GH deficiency, GH therapy can significantly improve symptoms of neuromuscular dysfunction. [382]