A large body of clinical trials suggests that IGF-1 has anti-cancer properties. In one of the largest studies ever conducted on IGF-1 and cancer, a long-term follow-up surveillance data involving 13,581 patients diagnosed with common cancers who are treated with IGF-1, did not show any increase in the risk of disease recurrence or death in cancer survivors.  In another large study by Swerdlow et al., GH and IGF-1 treatment in patients with brain tumors did not increase the risk of recurrence.  Data from the Childhood Cancer Survivor Study (CCSS) are also consistent with the finding that IGF-1 and GH administration do not increase risk of disease recurrence in patients with primary brain tumors and acute leukemia.  Furthermore, data from the two largest international databases and surveillance studies involving 86,000 patients on GH and IGF-1 therapy have shown no significant increase in cancer incidence.  In another study, researchers revealed that GH and IGF-1 levels approximately 10% that of normal showed almost complete growth suppression of transplanted human breast cancer cells.  Finally, there is compelling evidence that IGF-1 regulates hematopoiesis, a process that gives rise to all the other blood cells including neutrophils, macrophages, cytotoxic natural killer cells, and granulocytes – all of which helps protect the body against disease-causing microorganisms such as cancer cells.  Also, IGF-1 reduces inflammation  and blood sugar. It is a well-known fact that long-term inflammation [264-272] and elevated blood sugar levels [273-280] are risk factors that feed cancer growth or development. In addition, studies show that the anti-tumor properties of IGF-1 can be attributed to its ability to enhance natural killer cell activity of the immune system. [281-283]
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