IGF-1 and IGFBP (Insulin-like Growth Factor Binding Protein) axis plays a critical role in the maintenance of normal kidney function and progression of chronic kidney disease (CKD).  In fact, the levels of IGF-1 and IGFBPs are altered in different stages of CKD. One study revealed that short-term administration of recombinant IGF-1 (rhIGF-1) in patients with end-stage renal disease (ESRD) and in healthy subjects has been shown to increase glomerular filtration rate (GFR) and blood flow to the kidneys.  In another study, Vijayan et al. reported that IGF-1 supplementation in 15 patients with advanced CKD at a dose of 100 micrograms per kilogram twice daily for 31 days improved the kidney’s ability to filter waste products and toxins as evidenced by an increase in GFR.  Other clinical trials assessing the therapeutic benefits of IGF-1 supplementation in patients with kidney disorders have also shown that the treatment may help improve symptoms and overall kidney function. [177-186]
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