IGF-1 and Nerve Damage

Neuropathy is the term used to describe a problem with the nerves, typically causing numbness and problems with mobility. [140] Preclinical studies suggest that IGF-1 can be useful for the treatment of mixed motor and sensory neuropathies. The successful use of IGF-1 in the treatment of peripheral neuropathies may provide the first true therapy for this previously untreatable group of neurological disorders. In one study, Schmidt et al. reported that IGF-1 treatment for a period of 2 months resulted in nearly complete normalization of diabetic neuropathy without altering the severity of diabetes. [141] In another study, therapeutic administration of IGF-1 slowed the degeneration of spinal cord motor neuron axons by reducing the incidence of programmed cell death.[142] Several recent studies involving IGF-1 treatment for Duchenne Muscular Dystrophy (DMD), one of the most prevalent muscle disorders, have also shown significant improvements in muscle functional recovery after the treatment. [143] Similarly, other studies assessing the therapeutic benefits of IGF-1 therapy in a wide array of medical conditions related to nerve damage have shown that the treatment may help restore nerve function and sensation. [144-157]

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