With advancing age, all cells in the body are less able to divide and multiply.  In addition to this, many cells lose their ability to function, or they function abnormally. Aside from these changes, many tissues and organs lose mass and fail to function normally. This process is medically known as organ atrophy. When an organ loses mass and is worked harder than usual, it may lead to sudden failure or other life-threatening problems. There is increasing body of evidence that aside from aging, a process known as endothelial dysfunction can potentially contribute to organ atrophy and dysfunction. [296-301] Of note, studies show that IGF-1 can directly oppose endothelial dysfunction by increasing the production of nitric oxide, promoting insulin sensitivity, promoting potassium-channel opening, improving lipid profiles, and through IGF-1’s anti-apoptotic and anti-inflammatory properties. [302-306] Other studies assessing the therapeutic benefits of IGF-1 have also shown that this hormone may help prevent atrophy of the gut and brain. These findings suggest that IGF-1 does have the ability to fight internal signs of aging. [306-310]
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