Wound healing is a complex process which is affected by IGF-1 bound to insulin-like growth factor-binding protein (IGFBP).  This growth factor has receptors which stimulate local collagen formation necessary for wound healing.  In addition, IGF-1 and other growth factors modulate skin cell survival and regeneration.  A study performed to support the wound healing effects of IGF-1 showed that patients receiving 0.2 mg/kg/day recombinant human growth hormone (rHGH) demonstrated significantly higher IGF-1 blood levels and a significant decrease in donor-site healing times and length of hospital stay.  In another study, Aydin et al. reported that diabetic patients who had higher levels of IGF-1 had improved wound healing rate compared to those with lower levels.  Other studies assessing the therapeutic benefits of IGF-1 in patients with chronic wound have shown that the treatment speeds up the repair of damaged tissues by increasing the number of cells necessary for the wound healing process. [128-139]
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