Protects Against Nerve Damage

As a C-terminal tripeptide of α-MSH, KPV exerts protective effects against various forms of nerve damage, suggesting that it can help combat the effect of aging and other medical conditions on nerve health:
1. In neonatal rats with nerve injury, KPV effectively induced sciatic nerve regeneration. [60-61]
2. A cell study found that KPV stimulated growth of the long threadlike part of a nerve cell called axon. [62]
3. In a rat model of spinal cord injury, application of α-MSH cream shortly after trauma in high does induced nerve protection. [63]
4. In cultured rat brain cells, treatment with 10 nM α-MSH protected against cisplatin-induced neurotoxicity. [64-65]
5. A cell study also found that α-MSH protects against nerve damage by blocking signals involved in programmed cell death. [66-67]
6. Studies found that α-MSH protects nerve cells against ultraviolet radiation-induced apoptosis and DNA damage. [68-71]
7. Studies show that α-MSH may help protect nerve cells through its anti-scarring properties. [72-75]
8. In rats, local delivery of α-MSH can increase postlesional repair of nerve. [76-77]
9. Rat studies also show that α-MSH treatment can significantly improve neurological and electrophysiological function of damaged spinal cord. [78-81]

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