Treats a Wide Array of Inflammatory Conditions

An overwhelming body of clinical evidence suggests that KPV exerts its strong anti-inflammatory properties through various important mechanisms:
1. In mice model of colitis (colon inflammation), oral administration of KPV (added to drinking water) inhibited the activation of NF-κB and MAP kinase inflammatory signaling pathways and reduced pro-inflammatory cytokine secretion. [1]
2. A 2001 study published in Biochem Pharmacology found that KPV exerts its anti-inflammatory activities through inhibition of NF-kappaB translocation and activation of MC(1) receptor/cAMP. [2-3]
3. In animal model of colitis, KPV significantly reduced intestinal inflammation. [4-5]
4. As a C-terminal tripeptide of α-MSH, KPV fights inflammation by inhibiting tumor necrosis factor-α stimulated NF-κB activity and suppressing antigen-induced lymphocyte proliferation. [6-7]
5. A study published in the Journal of Federation of American Societies for Experimental Biology found that KPV suppresses inflammation through modulation of physiological responses in host defense. [8]
6. A 2003 study published in the Journal of Pharmacology and Experimental Therapeutics found that KPV exhibits its anti-inflammatory effect through inhibition of IL-1beta functions. [9]
7. A 2006 study published in the Basic & Clinical Pharmacology & Toxicology found that KPV fights inflammation by stimulating cAMP generation in a concentration dependent way. [10]
8. One study found that KPV combats inflammation by significantly inhibiting NF-kappaB-luciferase activity. [11]
9. A 2010 study published in Advances in Experimental Medicine and Biology reported that KPV has significant similarities between anti-inflammatory signaling of α-MSH. [12]
10. Several studies have shown a significant reduction of pro‐inflammatory substances such as IL1 β, IL6, TNFα, IL8, Groα and interferon γ (IFNγ) following KPV treatment. [13-14]
11. A cell study found that KPV produced antibody against the inflammatory IL10. [15]
12. Studies also show that KPV reduces inflammation through inhibition of inflammatory cell adhesion and transmigration. [16-17]

before after

At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

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