Preventing bone loss and increasing bone formation are two important mechanisms involved in maintaining optimum bone health. Studies show that LGD-4033 does have potent bone-building capacity and may help prevent osteoporosis and fractures:
1. LGD-4033 appears to decrease bone breakdown, thereby preventing fractures and decreased bone mineral density (BMD). 
2. In patients with osteoporosis, SARMs such as LGD-4033 increases BMD. 
3. In preclinical models, LGD-4033 increases BMD and bone strength at various skeletal sites. 
4. In rats, LGD-4033 promotes bone growth, prevents bone breakdown, and increases skeletal muscle mass/strength. [15-18]
5. In animal models, LGD-4033 accelerates healing of bone injuries. 
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