Fights Aging and Increases Longevity

Metformin also has anti-aging benefits. According to studies, it can block or diminish various fundamental factors that accelerate the aging process:
1. Metformin has been shown to slow the process of aging and prevent age-related diseases by protecting against DNA damage, poor mitochondrial function, and chronic inflammation. [132-136]
2. Metformin has also been shown to increase the cellular production of mTOR and AMPK, which are longevity-promoting signaling molecules. [137-142]
3. Animal studies have shown that metformin can increase lifespan by 20%. [143-144]
4. A study found that diabetics taking metformin lived 15% longer than healthy non-diabetic individuals. [145]
5. In different mouse breeds, long-term treatment with metformin extended lifespan. [146]
6. In the United Kingdom Prospective Diabetes Study (UKPDS), metformin therapy increased life expectancy by reducing the risk of cardiovascular disease, cancer incidence, and overall mortality of diabetic patients. [147-148]
7. Studies found that metformin can reduce the levels of reactive oxygen species (ROS), which are the major cause of aging. [149-153]
8. A study found that metformin combats the effects of aging by suppressing inflammatory response via inhibition of nuclear factor κB (NFκB). [154-155]
9. A cell study found that metformin exerts its anti-aging effect by preventing cellular senescence (irreversible cell cycle arrest). [156-157]
10. In several rodent strains, adding metformin to the diet resulted in a significant increase in lifespan (14-40%). [158-161]
11. In a model of Huntington’s disease, metformin extended lifespan by 20%. [162]
12. In diabetic and cardiovascular disease patients, metformin increased rates of survival. [163-164]
13. In older adults with type 2 diabetes, metformin administration may help promote longevity by preventing frailty. [165]
14. Cell studies have shown that metformin may help combat internal aging by reducing neuronal injury and improving oxygen/glucose delivery to neurons. [166-169]

before after

At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

- Nick Cassavetes, 60 yrs old

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