Promotes Weight Loss

The benefits of metformin go beyond improving blood sugar levels. Studies show that this antidiabetic drug can also benefit obese and overweight individuals by promoting weight loss:
1. A 10-year follow-up study on obese patients with type 2 diabetes revealed reductions in body weight in the group treated with metformin compared to placebo. [30]
2. In obese individuals with type 2 diabetes, metformin administration for 6 months caused a mean weight loss of 7 kg. [31]
3. In the Diabetes Prevention Program (DPP) study, participants who took metformin had reduced body weight and waist circumference compared with placebo. [32]
4. In overweight patients with type 2 diabetes, metformin treatment was associated with lesser weight gain. [33]
5. In obese children and adolescents, metformin was associated with short-term weight loss, improvement of insulin sensitivity, and decreased visceral fat. [34]
6. In overweight and obese patients, metformin induced weight loss by improving leptin and insulin sensitivity. [35]
7. In clinically stable, overweight patients with chronic mental health disorder, metformin was modestly effective in reducing weight. [36]
8. In obese insulin-resistant patients participating in a low-intensity weight-reduction program, metformin had favourable effects on body weight and body composition. [37]
9. In overweight and obese patients, metformin treatment reduced waist-to-hip ratio. [38]
10. In obese patients with type 2 diabetes, 700-mg dose of metformin induced weight loss by decreasing food consumption. [39]
11. In Bahraini patients aged 20 or more, metformin treatment was associated with weight loss of 1-10 kg. [40]
12. In elderly participants (60 years and above), metformin reduced body weight without any adverse side effects. [41]
13. In obese, insulin-resistant adolescents, long-term treatment with metformin resulted in stabilization of body mass index (BMI) and improved body composition. [42]
14. In patients with antipsychotic-induced weight gain, metformin treatment resulted in significant weight reduction. [43-47]
15. In women with polycystic ovary syndrome, treatment with 850 mg of metformin twice daily for 6 months reduced weight by an average of 9.24 pounds. [48]

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