Treats Diabetes Symptoms and Improves Blood Sugar Levels

Combating diabetes by reducing blood sugar is the main indication of metformin. An overwhelming body of clinical trials support metformin’s beneficial effects on blood sugar levels:
1. In a study published by the American Diabetes Association, metformin decreased blood sugar levels by 60 to 70 mg/dl in patients with non-insulin dependent type II diabetes. [1]
2. Metformin has been shown to reduce the incidence of deaths related to diabetic complications by 30% compared to other medications for diabetes such as insulin, glibenclamide and chlorpropamide. [2]
3. In patients with pre-diabetes, metformin administration reduced the chance of developing type 2 diabetes mellitus 31%. [3]
4. A clinical trial found that metformin and insulin have similar safety and efficacy in the treatment of gestational diabetes. [4]
5. In pregnant women, treatment of metformin instead of insulin was associated with less weight gain and improved neonatal outcomes. [5]
6. In patients with type 2 diabetes and impaired glucose tolerance, the combination of metformin and lifestyle interventions delayed the progression of the disease. [6]
7. In the Diabetes Prevention Program (DPP) trial, lifestyle intervention and metformin reduced the incidence of diabetes by 58% and 31%. [7-8]
8. In a Chinese study, subjects with impaired glucose tolerance who received low-dose metformin (750 mg/day) produced large, significant reductions for new onset of type 2 diabetes. [9-10]
9. A study found that metformin treatment was associated with a 40% reduction in the incidence of new-onset diabetes with an absolute risk reduction of 6% during a mean trial duration of 1.8 years. [11]
10. In patients with impaired glucose tolerance and impaired fasting glucose, both higher and lower metformin dosage decreased rate of conversion from pre-diabetes to diabetes. [12]
11. In patients with type 2 diabetes, early initiation of metformin is recommended as a first-line drug for monotherapy and combination therapy. [13-14]
12. In obese patients with type 2 diabetes mellitus, metformin administration is as effective as sulfonylurea, an antidiabetic drug, in controlling blood sugar levels. [15-16]
13. In patients sub-optimally controlled by diet and exercise, combination of metformin and insulin secretagogue reduced HbA1c (an indicator of blood sugar control) between 1.5% to 2.2%. [17-19]
14. Combination of metformin with other antidiabetic drugs such as sulfonylureas and alpha-glucosidase inhibitors significantly reduced HbA1c. [20]
15. Combination of metformin and the oral antidiabetic drug glimepiride in diabetic patients resulted in a lower HbA1c concentration and fewer hypoglycemic events (abnormally low blood sugar). [21]
16. The combination of metformin and sulfonylurea was also associated with reduced all-cause mortality. [22]
17. Metformin as added to insulin-based regimens has been shown to improve blood sugar control, and reduce body weight, hypoglycemic events, insulin requirements and total insulin dosage. [23-26]
18. In patients with type 2 diabetes, combination of metformin and dapagliflozin reduced the incidence of hyperglycemia (high blood sugar). [27-28]
19. The combination of saxagliptin and metformin led to clinically and statistically significant reductions in HbA1c. [29]

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