Treats Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is a hormonal disorder caused by collection of several fluids (follicles) in the ovaries, affecting its ability to release eggs. Studies show that metformin may help treat this debilitating condition:
1. In patients with PCOS, metformin helps reverse metabolic abnormalities including insulin resistance, hypertension, and abnormal lipid profiles. [109-110]
2. The mechanisms by which metformin exerts its beneficial effects on PCOS is through increased insulin sensitivity, increased secretion of estrogen by the ovaries, decreased production of androgen, and enhanced production of sex hormone binding globulin. [111-112]
3. In non-obese women with PCOS, metformin administration induced ovulation. [113-114]
4. In women with PCOS, metformin therapy was associated with significant improvement in menstrual regularity and reduction in circulating androgen levels. [115]
5. Metformin therapy in patients with PCOS improved ovarian steroidogenesis (production of estrogen and progesterone). [116-117]
6. Metformin administration in women with PCOS was associated with improved ovulation, pregnancy, and live birth rates. [118]
7. In patients with PCOS undergoing in vitro fertilization, metformin treatment improved the quality of egg and embryos. [119-120]
8. In anovulatory women with PCOS, metformin normalized ovarian follicular development and uterine blood flow. [121]
9. In PCOS patients, metformin administration reduced the risk of miscarriage. [122-124]