The age-related decline in bone mineral density causes osteoporosis and fractures. Studies show that MOTS-c can help correct these problems by improving bone quality and preventing bone-damaging processes:
1. In mice, MOTS-c injection at a dose of 5 mg/kg once a day for 12 weeks alleviated bone loss by inhibiting the process of bone breakdown (osteoclastogenesis). 
2. In rats, MOTS-c treatment improved osteoporosis by boosting the production of bone mesenchymal stem cells (BMSCs), which are cells that can transform into bone-forming cells (osteoblasts). 
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