Evidence also suggests that MOTS-c can help preserve heart function by combating the detrimental effects of inflammation on the body and that its levels correlate with cardiovascular health:
1. In human subjects, lower circulating MOTS-c levels were associated with impaired coronary endothelial function. 
2. In cold-exposed rats, MOTS-c prevented blood vessel dysfunction of the heart. 
3. A study found that MOTS-c may help reduce endothelial dysfunction by suppressing inflammatory pathways such as MAPK/NF-κB. 
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