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GENEMEDICS NUTRITION
The aging population is highly at risk for sleeping problems and disorders that can significantly affect their quality of life. Whether it is age-related or caused by a certain medical condition, MK-677 supplementation may help improve sleep quality and quantity according to numerous clinical research:
1. In both younger and elderly subjects, MK-677 treatment for 14 days improves sleep quality by increasing rapid eye movement (REM) sleep duration by 50%. [57]
2. In healthy older adults, oral administration of MK-677 (25 mg) once daily improves Pittsburgh Sleep Quality Index, a measure of sleep. [58]
3. In normal men, administration of growth hormone secretagogue increases slow-wave sleep (SWS), which is often referred to as deep sleep. [59]
4. In young healthy men, intravenous injections of growth hormone secretagogue during sleep consistently stimulate slow-wave sleep, suggesting that MK-677 may help improve sleep quality. [60]
5. In normal young males, growth hormone secretagogue administration increases stage 2 sleep. [61]
6. Higher GH levels are strongly associated with improved deep sleep stage, indicating that MK-677 supplementation may have positive effect on sleep. [62-67]
7. Higher IGF-1 levels are also linked with better sleep, suggesting that MK-677 supplementation may have beneficial effects. [68-78]
8. Studies on rats show that growth hormone secretagogue administration activates sleep regulatory neurons in the brain. [79]
9. In obese patients, growth hormone secretagogue administration improves stage 2 sleep by reversing GH deficiency. [80-81]
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