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Modafinil is not only a cognitive enhancer but it’s also a mood booster. There’s a good deal of evidence to back up the beneficial effects of modafinil on overall mood:
1. In normal healthy men and women, administration of modafinil increased general mood. [116]
2. In healthy individuals, administration of modafinil increased alertness and improved mood. [117]
3. In healthy, non sleep-deprived students, modafinil administration at a dose of 100-200 mg decreased measures of anxiety such as shaking, palpitations, restlessness, muscular tension, and irritability. [118]
4. In patients with myotonic dystrophy, modafinil reduced excessive somnolence and enhanced mood. [119]
5. In patients with mood disorder, modafinil relieved symptoms of depression without any adverse side effects. [120-122]
6. In narcolepsy patients who were switched from psychostimulants, administration of modafinil at 200-400 mg once daily for 6 weeks improved subjective feelings of vigor. [123]
7. In sleep-deprived pilots, modafinil administration at a dose of 100 mg improved simulator performance and mood. [124-125]
8. Modafinil has been shown to be more effective than placebo in treating symptoms of bipolar depression. [126]
9. In patients with attention-deficit/hyperactivity disorder, modafinil film-coated tablets significantly improved symptoms with fewer side effects. [127-136]
10. In patients with spinal cord injury, modafinil administration increased self-esteem and motivation, as well as decreased self-consciousness. [137]
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