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The ability of phentermine to dramatically reduce weight without untoward side effects is backed by a number of high quality studies:
1. An analysis of several clinical trials found that phentermine can result in a weight loss of 3.6 kg at six months compared with placebo treatment. [2]
2. In obese subjects, phentermine administration initially at 15 mg daily and slowly up-titrated to 37.5 mg daily resulted in 13% reduction in baseline peak weight. [3]
3. In obese or overweight patients with weight-related comorbidities, treatment with phentermine consistently demonstrated statistically significant weight loss after 56 weeks compared with placebo. [4-5]
4. When combined with other weight loss drugs, phentermine can produce greater weight loss. [6-14]
5. In one-hundred-eight obese women, continuous daily phentermine administration resulted in a mean weight loss of 27 pounds (12.2 kg) while intermittent phentermine (4 weeks on therapy and 4 weeks off of therapy) resulted in a mean weight loss of 28.7 pounds (13 kg). [15]
6. Several studies also found that phentermine only reduces weight during the time that it is being taken. [16-22]
7. When combined with topiramate, an anti-seizure drug, phentermine produced significant weight loss without any adverse side effects. [23-29]
8. Studies suggest that phentermine promotes weight loss by inducing changes in eating behavior. [30-34]
9. Studies found that overweight and obese patients as young as 3 years and as old as 88 years can be safely treated with phentermine. [35-36]
10. An analysis of 6 studies found that patients using 15–30 mg of phentermine daily for 2 to 24 weeks had a mean total weight loss of 6.3 kg. [37]
11. In healthy obese people, short-term phentermine administration significantly reduced weight and waist circumference without clinically problematic adverse events. [38]
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